Cembranoids from Octocoral Lobophytum crassum (von Marenzeller, 1886)

Two cembranoids, including a new compound, lobocrassin I (1), as well as a known analogue, lobohedleolide (2), were obtained by solvent extraction from octocoral Lobophytum crassum. This study employed a spectroscopic approach to establish the structures of these two cembranoids, and utilized single...

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Detalles Bibliográficos
Autores principales: Yeh, Yao-Tsung, Lin, Sung-Chun, Lee, Gene-Hsiang, Wen, Zhi-Hong, Hwang, Tsong-Long, Wu, Yu-Jen, Chen, Jih-Jung, Fang, Lee-Shing, Yuan, Mei-Kang, Sung, Ping-Jyun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7997245/
https://www.ncbi.nlm.nih.gov/pubmed/33673526
http://dx.doi.org/10.3390/md19030130
Descripción
Sumario:Two cembranoids, including a new compound, lobocrassin I (1), as well as a known analogue, lobohedleolide (2), were obtained by solvent extraction from octocoral Lobophytum crassum. This study employed a spectroscopic approach to establish the structures of these two cembranoids, and utilized single-crystal X-ray diffraction analysis to determine their absolute configurations. The results of biological activity assays demonstrated that cembranoid 2 exhibited bioactivity against the protein expressions of inducible nitric oxide synthase (iNOS) lipopolysaccharide (LPS)-treated RAW 264.7 mouse macrophage cells.

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