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Cembranoids from Octocoral Lobophytum crassum (von Marenzeller, 1886)
Two cembranoids, including a new compound, lobocrassin I (1), as well as a known analogue, lobohedleolide (2), were obtained by solvent extraction from octocoral Lobophytum crassum. This study employed a spectroscopic approach to establish the structures of these two cembranoids, and utilized single...
| Autores principales: | , , , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
MDPI
2021
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7997245/ https://www.ncbi.nlm.nih.gov/pubmed/33673526 http://dx.doi.org/10.3390/md19030130 |
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| author | Yeh, Yao-Tsung Lin, Sung-Chun Lee, Gene-Hsiang Wen, Zhi-Hong Hwang, Tsong-Long Wu, Yu-Jen Chen, Jih-Jung Fang, Lee-Shing Yuan, Mei-Kang Sung, Ping-Jyun |
| author_facet | Yeh, Yao-Tsung Lin, Sung-Chun Lee, Gene-Hsiang Wen, Zhi-Hong Hwang, Tsong-Long Wu, Yu-Jen Chen, Jih-Jung Fang, Lee-Shing Yuan, Mei-Kang Sung, Ping-Jyun |
| author_sort | Yeh, Yao-Tsung |
| collection | PubMed |
| description | Two cembranoids, including a new compound, lobocrassin I (1), as well as a known analogue, lobohedleolide (2), were obtained by solvent extraction from octocoral Lobophytum crassum. This study employed a spectroscopic approach to establish the structures of these two cembranoids, and utilized single-crystal X-ray diffraction analysis to determine their absolute configurations. The results of biological activity assays demonstrated that cembranoid 2 exhibited bioactivity against the protein expressions of inducible nitric oxide synthase (iNOS) lipopolysaccharide (LPS)-treated RAW 264.7 mouse macrophage cells. |
| format | Online Article Text |
| id | pubmed-7997245 |
| institution | National Center for Biotechnology Information |
| language | English |
| publishDate | 2021 |
| publisher | MDPI |
| record_format | MEDLINE/PubMed |
| spelling | pubmed-79972452021-03-27 Cembranoids from Octocoral Lobophytum crassum (von Marenzeller, 1886) Yeh, Yao-Tsung Lin, Sung-Chun Lee, Gene-Hsiang Wen, Zhi-Hong Hwang, Tsong-Long Wu, Yu-Jen Chen, Jih-Jung Fang, Lee-Shing Yuan, Mei-Kang Sung, Ping-Jyun Mar Drugs Article Two cembranoids, including a new compound, lobocrassin I (1), as well as a known analogue, lobohedleolide (2), were obtained by solvent extraction from octocoral Lobophytum crassum. This study employed a spectroscopic approach to establish the structures of these two cembranoids, and utilized single-crystal X-ray diffraction analysis to determine their absolute configurations. The results of biological activity assays demonstrated that cembranoid 2 exhibited bioactivity against the protein expressions of inducible nitric oxide synthase (iNOS) lipopolysaccharide (LPS)-treated RAW 264.7 mouse macrophage cells. MDPI 2021-02-27 /pmc/articles/PMC7997245/ /pubmed/33673526 http://dx.doi.org/10.3390/md19030130 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) ). |
| spellingShingle | Article Yeh, Yao-Tsung Lin, Sung-Chun Lee, Gene-Hsiang Wen, Zhi-Hong Hwang, Tsong-Long Wu, Yu-Jen Chen, Jih-Jung Fang, Lee-Shing Yuan, Mei-Kang Sung, Ping-Jyun Cembranoids from Octocoral Lobophytum crassum (von Marenzeller, 1886) |
| title | Cembranoids from Octocoral Lobophytum crassum (von Marenzeller, 1886) |
| title_full | Cembranoids from Octocoral Lobophytum crassum (von Marenzeller, 1886) |
| title_fullStr | Cembranoids from Octocoral Lobophytum crassum (von Marenzeller, 1886) |
| title_full_unstemmed | Cembranoids from Octocoral Lobophytum crassum (von Marenzeller, 1886) |
| title_short | Cembranoids from Octocoral Lobophytum crassum (von Marenzeller, 1886) |
| title_sort | cembranoids from octocoral lobophytum crassum (von marenzeller, 1886) |
| topic | Article |
| url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7997245/ https://www.ncbi.nlm.nih.gov/pubmed/33673526 http://dx.doi.org/10.3390/md19030130 |
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