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Outcome Prediction in Patients with Severe COVID-19 Requiring Extracorporeal Membrane Oxygenation—A Retrospective International Multicenter Study
The role of veno-venous extracorporeal membrane oxygenation therapy (V-V ECMO) in severe COVID-19 acute respiratory distress syndrome (ARDS) is still under debate and conclusive data from large cohorts are scarce. Furthermore, criteria for the selection of patients that benefit most from this highly...
Autores principales: | , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7997249/ https://www.ncbi.nlm.nih.gov/pubmed/33673615 http://dx.doi.org/10.3390/membranes11030170 |
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author | Supady, Alexander DellaVolpe, Jeff Taccone, Fabio Silvio Scharpf, Dominik Ulmer, Matthias Lepper, Philipp M. Halbe, Maximilian Ziegeler, Stephan Vogt, Alexander Ramanan, Raj Boldt, David Stecher, Stephanie-Susanne Montisci, Andrea Spangenberg, Tobias Marggraf, Olivier Kunavarapu, Chandra Peluso, Lorenzo Muenz, Sebastian Buerle, Monica Nagaraj, Naveen G. Nuding, Sebastian Toma, Catalin Gudzenko, Vadim Stemmler, Hans Joachim Pappalardo, Federico Trummer, Georg Benk, Christoph Michels, Guido Duerschmied, Daniel von zur Muehlen, Constantin Bode, Christoph Kaier, Klaus Brodie, Daniel Wengenmayer, Tobias Staudacher, Dawid L. |
author_facet | Supady, Alexander DellaVolpe, Jeff Taccone, Fabio Silvio Scharpf, Dominik Ulmer, Matthias Lepper, Philipp M. Halbe, Maximilian Ziegeler, Stephan Vogt, Alexander Ramanan, Raj Boldt, David Stecher, Stephanie-Susanne Montisci, Andrea Spangenberg, Tobias Marggraf, Olivier Kunavarapu, Chandra Peluso, Lorenzo Muenz, Sebastian Buerle, Monica Nagaraj, Naveen G. Nuding, Sebastian Toma, Catalin Gudzenko, Vadim Stemmler, Hans Joachim Pappalardo, Federico Trummer, Georg Benk, Christoph Michels, Guido Duerschmied, Daniel von zur Muehlen, Constantin Bode, Christoph Kaier, Klaus Brodie, Daniel Wengenmayer, Tobias Staudacher, Dawid L. |
author_sort | Supady, Alexander |
collection | PubMed |
description | The role of veno-venous extracorporeal membrane oxygenation therapy (V-V ECMO) in severe COVID-19 acute respiratory distress syndrome (ARDS) is still under debate and conclusive data from large cohorts are scarce. Furthermore, criteria for the selection of patients that benefit most from this highly invasive and resource-demanding therapy are yet to be defined. In this study, we assess survival in an international multicenter cohort of COVID-19 patients treated with V-V ECMO and evaluate the performance of several clinical scores to predict 30-day survival. Methods: This is an investigator-initiated retrospective non-interventional international multicenter registry study (NCT04405973, first registered 28 May 2020). In 127 patients treated with V-V ECMO at 15 centers in Germany, Switzerland, Italy, Belgium, and the United States, we calculated the Sequential Organ Failure Assessment (SOFA) Score, Simplified Acute Physiology Score II (SAPS II), Acute Physiology And Chronic Health Evaluation II (APACHE II) Score, Respiratory Extracorporeal Membrane Oxygenation Survival Prediction (RESP) Score, Predicting Death for Severe ARDS on V-V ECMO (PRESERVE) Score, and 30-day survival. Results: In our study cohort which enrolled 127 patients, overall 30-day survival was 54%. Median SOFA, SAPS II, APACHE II, RESP, and PRESERVE were 9, 36, 17, 1, and 4, respectively. The prognostic accuracy for all these scores (area under the receiver operating characteristic—AUROC) ranged between 0.548 and 0.605. Conclusions: The use of scores for the prediction of mortality cannot be recommended for treatment decisions in severe COVID-19 ARDS undergoing V-V ECMO; nevertheless, scoring results below or above a specific cut-off value may be considered as an additional tool in the evaluation of prognosis. Survival rates in this cohort of COVID-19 patients treated with V-V ECMO were slightly lower than those reported in non-COVID-19 ARDS patients treated with V-V ECMO. |
format | Online Article Text |
id | pubmed-7997249 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-79972492021-03-27 Outcome Prediction in Patients with Severe COVID-19 Requiring Extracorporeal Membrane Oxygenation—A Retrospective International Multicenter Study Supady, Alexander DellaVolpe, Jeff Taccone, Fabio Silvio Scharpf, Dominik Ulmer, Matthias Lepper, Philipp M. Halbe, Maximilian Ziegeler, Stephan Vogt, Alexander Ramanan, Raj Boldt, David Stecher, Stephanie-Susanne Montisci, Andrea Spangenberg, Tobias Marggraf, Olivier Kunavarapu, Chandra Peluso, Lorenzo Muenz, Sebastian Buerle, Monica Nagaraj, Naveen G. Nuding, Sebastian Toma, Catalin Gudzenko, Vadim Stemmler, Hans Joachim Pappalardo, Federico Trummer, Georg Benk, Christoph Michels, Guido Duerschmied, Daniel von zur Muehlen, Constantin Bode, Christoph Kaier, Klaus Brodie, Daniel Wengenmayer, Tobias Staudacher, Dawid L. Membranes (Basel) Article The role of veno-venous extracorporeal membrane oxygenation therapy (V-V ECMO) in severe COVID-19 acute respiratory distress syndrome (ARDS) is still under debate and conclusive data from large cohorts are scarce. Furthermore, criteria for the selection of patients that benefit most from this highly invasive and resource-demanding therapy are yet to be defined. In this study, we assess survival in an international multicenter cohort of COVID-19 patients treated with V-V ECMO and evaluate the performance of several clinical scores to predict 30-day survival. Methods: This is an investigator-initiated retrospective non-interventional international multicenter registry study (NCT04405973, first registered 28 May 2020). In 127 patients treated with V-V ECMO at 15 centers in Germany, Switzerland, Italy, Belgium, and the United States, we calculated the Sequential Organ Failure Assessment (SOFA) Score, Simplified Acute Physiology Score II (SAPS II), Acute Physiology And Chronic Health Evaluation II (APACHE II) Score, Respiratory Extracorporeal Membrane Oxygenation Survival Prediction (RESP) Score, Predicting Death for Severe ARDS on V-V ECMO (PRESERVE) Score, and 30-day survival. Results: In our study cohort which enrolled 127 patients, overall 30-day survival was 54%. Median SOFA, SAPS II, APACHE II, RESP, and PRESERVE were 9, 36, 17, 1, and 4, respectively. The prognostic accuracy for all these scores (area under the receiver operating characteristic—AUROC) ranged between 0.548 and 0.605. Conclusions: The use of scores for the prediction of mortality cannot be recommended for treatment decisions in severe COVID-19 ARDS undergoing V-V ECMO; nevertheless, scoring results below or above a specific cut-off value may be considered as an additional tool in the evaluation of prognosis. Survival rates in this cohort of COVID-19 patients treated with V-V ECMO were slightly lower than those reported in non-COVID-19 ARDS patients treated with V-V ECMO. MDPI 2021-02-27 /pmc/articles/PMC7997249/ /pubmed/33673615 http://dx.doi.org/10.3390/membranes11030170 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) ). |
spellingShingle | Article Supady, Alexander DellaVolpe, Jeff Taccone, Fabio Silvio Scharpf, Dominik Ulmer, Matthias Lepper, Philipp M. Halbe, Maximilian Ziegeler, Stephan Vogt, Alexander Ramanan, Raj Boldt, David Stecher, Stephanie-Susanne Montisci, Andrea Spangenberg, Tobias Marggraf, Olivier Kunavarapu, Chandra Peluso, Lorenzo Muenz, Sebastian Buerle, Monica Nagaraj, Naveen G. Nuding, Sebastian Toma, Catalin Gudzenko, Vadim Stemmler, Hans Joachim Pappalardo, Federico Trummer, Georg Benk, Christoph Michels, Guido Duerschmied, Daniel von zur Muehlen, Constantin Bode, Christoph Kaier, Klaus Brodie, Daniel Wengenmayer, Tobias Staudacher, Dawid L. Outcome Prediction in Patients with Severe COVID-19 Requiring Extracorporeal Membrane Oxygenation—A Retrospective International Multicenter Study |
title | Outcome Prediction in Patients with Severe COVID-19 Requiring Extracorporeal Membrane Oxygenation—A Retrospective International Multicenter Study |
title_full | Outcome Prediction in Patients with Severe COVID-19 Requiring Extracorporeal Membrane Oxygenation—A Retrospective International Multicenter Study |
title_fullStr | Outcome Prediction in Patients with Severe COVID-19 Requiring Extracorporeal Membrane Oxygenation—A Retrospective International Multicenter Study |
title_full_unstemmed | Outcome Prediction in Patients with Severe COVID-19 Requiring Extracorporeal Membrane Oxygenation—A Retrospective International Multicenter Study |
title_short | Outcome Prediction in Patients with Severe COVID-19 Requiring Extracorporeal Membrane Oxygenation—A Retrospective International Multicenter Study |
title_sort | outcome prediction in patients with severe covid-19 requiring extracorporeal membrane oxygenation—a retrospective international multicenter study |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7997249/ https://www.ncbi.nlm.nih.gov/pubmed/33673615 http://dx.doi.org/10.3390/membranes11030170 |
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