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Association between Oncostatin M Expression and Inflammatory Phenotype in Experimental Arthritis Models and Osteoarthritis Patients

Pro-inflammatory cytokines are considered to play a major role in osteoarthritis (OA), yet so far, the specific cytokines involved in the pathology of OA have not been identified. Oncostatin M (OSM) is a cytokine from the interleukin 6 (IL-6) family that has been shown to be elevated in synovial flu...

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Autores principales: Garcia, Joao Pedro, Utomo, Lizette, Rudnik-Jansen, Imke, Du, Jie, Zuithoff, Nicolaas P.A., Krouwels, Anita, van Osch, Gerjo J.V.M., Creemers, Laura B.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7997294/
https://www.ncbi.nlm.nih.gov/pubmed/33673583
http://dx.doi.org/10.3390/cells10030508
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author Garcia, Joao Pedro
Utomo, Lizette
Rudnik-Jansen, Imke
Du, Jie
Zuithoff, Nicolaas P.A.
Krouwels, Anita
van Osch, Gerjo J.V.M.
Creemers, Laura B.
author_facet Garcia, Joao Pedro
Utomo, Lizette
Rudnik-Jansen, Imke
Du, Jie
Zuithoff, Nicolaas P.A.
Krouwels, Anita
van Osch, Gerjo J.V.M.
Creemers, Laura B.
author_sort Garcia, Joao Pedro
collection PubMed
description Pro-inflammatory cytokines are considered to play a major role in osteoarthritis (OA), yet so far, the specific cytokines involved in the pathology of OA have not been identified. Oncostatin M (OSM) is a cytokine from the interleukin 6 (IL-6) family that has been shown to be elevated in synovial fluid of most rheumatoid arthritis (RA) patients, but only in a limited subset of OA patients. Little is known about OSM in the different joint tissues during OA and how its expression correlates with hallmarks of disease. Here, we mapped OSM expression in the joint tissues of two rat models of arthritis: an acute inflammatory model and an instability-induced osteoarthritic model. OSM expression was correlated with hallmarks of OA, namely cartilage damage, synovitis, and osteophyte formation. Reanalysis of an existing dataset on cytokine profiling of OA synovial fluid was performed to assess pattern differences between patients positive and negative for OSM. In the inflammatory model, OSM expression correlated with synovitis and osteophyte formation but not with cartilage damage. On the contrary, in the instability model of OA, an increase in synovitis, cartilage damage, and osteophyte formation was observed without changes in OSM expression. In line with these findings, synovial fluid of OA patients with detectable OSM contained higher levels of other inflammatory cytokines, namely interferon gamma (IFN-γ), IL-1α and tumor necrosis factor alpha (TNF-α), likely indicating a more inflammatory state. Taken together these data indicate OSM might play a prominent role in inflammatory phenotypes of OA.
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spelling pubmed-79972942021-03-27 Association between Oncostatin M Expression and Inflammatory Phenotype in Experimental Arthritis Models and Osteoarthritis Patients Garcia, Joao Pedro Utomo, Lizette Rudnik-Jansen, Imke Du, Jie Zuithoff, Nicolaas P.A. Krouwels, Anita van Osch, Gerjo J.V.M. Creemers, Laura B. Cells Article Pro-inflammatory cytokines are considered to play a major role in osteoarthritis (OA), yet so far, the specific cytokines involved in the pathology of OA have not been identified. Oncostatin M (OSM) is a cytokine from the interleukin 6 (IL-6) family that has been shown to be elevated in synovial fluid of most rheumatoid arthritis (RA) patients, but only in a limited subset of OA patients. Little is known about OSM in the different joint tissues during OA and how its expression correlates with hallmarks of disease. Here, we mapped OSM expression in the joint tissues of two rat models of arthritis: an acute inflammatory model and an instability-induced osteoarthritic model. OSM expression was correlated with hallmarks of OA, namely cartilage damage, synovitis, and osteophyte formation. Reanalysis of an existing dataset on cytokine profiling of OA synovial fluid was performed to assess pattern differences between patients positive and negative for OSM. In the inflammatory model, OSM expression correlated with synovitis and osteophyte formation but not with cartilage damage. On the contrary, in the instability model of OA, an increase in synovitis, cartilage damage, and osteophyte formation was observed without changes in OSM expression. In line with these findings, synovial fluid of OA patients with detectable OSM contained higher levels of other inflammatory cytokines, namely interferon gamma (IFN-γ), IL-1α and tumor necrosis factor alpha (TNF-α), likely indicating a more inflammatory state. Taken together these data indicate OSM might play a prominent role in inflammatory phenotypes of OA. MDPI 2021-02-27 /pmc/articles/PMC7997294/ /pubmed/33673583 http://dx.doi.org/10.3390/cells10030508 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) ).
spellingShingle Article
Garcia, Joao Pedro
Utomo, Lizette
Rudnik-Jansen, Imke
Du, Jie
Zuithoff, Nicolaas P.A.
Krouwels, Anita
van Osch, Gerjo J.V.M.
Creemers, Laura B.
Association between Oncostatin M Expression and Inflammatory Phenotype in Experimental Arthritis Models and Osteoarthritis Patients
title Association between Oncostatin M Expression and Inflammatory Phenotype in Experimental Arthritis Models and Osteoarthritis Patients
title_full Association between Oncostatin M Expression and Inflammatory Phenotype in Experimental Arthritis Models and Osteoarthritis Patients
title_fullStr Association between Oncostatin M Expression and Inflammatory Phenotype in Experimental Arthritis Models and Osteoarthritis Patients
title_full_unstemmed Association between Oncostatin M Expression and Inflammatory Phenotype in Experimental Arthritis Models and Osteoarthritis Patients
title_short Association between Oncostatin M Expression and Inflammatory Phenotype in Experimental Arthritis Models and Osteoarthritis Patients
title_sort association between oncostatin m expression and inflammatory phenotype in experimental arthritis models and osteoarthritis patients
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7997294/
https://www.ncbi.nlm.nih.gov/pubmed/33673583
http://dx.doi.org/10.3390/cells10030508
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