Therapeutic Potential of Targeting Plasminogen Activator Inhibitor-1 in COVID-19

Latest research shows that SERPINE1 overexpression has an important role in Coronavirus 2019 (COVID-19)-associated coagulopathy leading to acute respiratory distress syndrome (ARDS). However, ways to target this protein remain elusive. In this forum, we discuss recent evidence linking SERPINE1 with...

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Detalles Bibliográficos
Autores principales: Kellici, Tahsin F., Pilka, Ewa S., Bodkin, Michael J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier Ltd. 2021
Materias:
Forum
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7997307/
https://www.ncbi.nlm.nih.gov/pubmed/33867130
http://dx.doi.org/10.1016/j.tips.2021.03.006
Descripción
Sumario:Latest research shows that SERPINE1 overexpression has an important role in Coronavirus 2019 (COVID-19)-associated coagulopathy leading to acute respiratory distress syndrome (ARDS). However, ways to target this protein remain elusive. In this forum, we discuss recent evidence linking SERPINE1 with COVID-19-related ARDS and summarize the available data on inhibitors of this target.

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