Therapeutic Potential of Targeting Plasminogen Activator Inhibitor-1 in COVID-19

Latest research shows that SERPINE1 overexpression has an important role in Coronavirus 2019 (COVID-19)-associated coagulopathy leading to acute respiratory distress syndrome (ARDS). However, ways to target this protein remain elusive. In this forum, we discuss recent evidence linking SERPINE1 with...

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Detalles Bibliográficos
Autores principales: Kellici, Tahsin F., Pilka, Ewa S., Bodkin, Michael J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier Ltd. 2021
Materias:
Forum
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7997307/
https://www.ncbi.nlm.nih.gov/pubmed/33867130
http://dx.doi.org/10.1016/j.tips.2021.03.006
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author Kellici, Tahsin F.
Pilka, Ewa S.
Bodkin, Michael J.
author_facet Kellici, Tahsin F.
Pilka, Ewa S.
Bodkin, Michael J.
author_sort Kellici, Tahsin F.
collection PubMed
description Latest research shows that SERPINE1 overexpression has an important role in Coronavirus 2019 (COVID-19)-associated coagulopathy leading to acute respiratory distress syndrome (ARDS). However, ways to target this protein remain elusive. In this forum, we discuss recent evidence linking SERPINE1 with COVID-19-related ARDS and summarize the available data on inhibitors of this target.
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spelling pubmed-79973072021-03-29 Therapeutic Potential of Targeting Plasminogen Activator Inhibitor-1 in COVID-19 Kellici, Tahsin F. Pilka, Ewa S. Bodkin, Michael J. Trends Pharmacol Sci Forum Latest research shows that SERPINE1 overexpression has an important role in Coronavirus 2019 (COVID-19)-associated coagulopathy leading to acute respiratory distress syndrome (ARDS). However, ways to target this protein remain elusive. In this forum, we discuss recent evidence linking SERPINE1 with COVID-19-related ARDS and summarize the available data on inhibitors of this target. Elsevier Ltd. 2021-06 2021-03-26 /pmc/articles/PMC7997307/ /pubmed/33867130 http://dx.doi.org/10.1016/j.tips.2021.03.006 Text en © 2021 Elsevier Ltd. All rights reserved. Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active.
spellingShingle Forum
Kellici, Tahsin F.
Pilka, Ewa S.
Bodkin, Michael J.
Therapeutic Potential of Targeting Plasminogen Activator Inhibitor-1 in COVID-19
title Therapeutic Potential of Targeting Plasminogen Activator Inhibitor-1 in COVID-19
title_full Therapeutic Potential of Targeting Plasminogen Activator Inhibitor-1 in COVID-19
title_fullStr Therapeutic Potential of Targeting Plasminogen Activator Inhibitor-1 in COVID-19
title_full_unstemmed Therapeutic Potential of Targeting Plasminogen Activator Inhibitor-1 in COVID-19
title_short Therapeutic Potential of Targeting Plasminogen Activator Inhibitor-1 in COVID-19
title_sort therapeutic potential of targeting plasminogen activator inhibitor-1 in covid-19
topic Forum
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7997307/
https://www.ncbi.nlm.nih.gov/pubmed/33867130
http://dx.doi.org/10.1016/j.tips.2021.03.006
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