Cargando…

Assessment of the Multifunctional Behavior of Lupin Peptide P7 and Its Metabolite Using an Integrated Strategy

[Image: see text] LTFPGSAED (P7) is a multifunctional hypocholesterolemic and hypoglycemic lupin peptide. While assessing its angiotensin-converting enzyme (ACE) inhibitory activity, it was more effective in intestinal Caco-2 cells (IC(50) of 13.7 μM) than in renal HK-2 cells (IC(50) of 79.6 μM). Th...

Descripción completa

Detalles Bibliográficos
Autores principales:	Lammi, Carmen, Aiello, Gilda, Dellafiora, Luca, Bollati, Carlotta, Boschin, Giovanna, Ranaldi, Giulia, Ferruzza, Simonetta, Sambuy, Yula, Galaverna, Gianni, Arnoldi, Anna
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Chemical Society 2020
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7997369/ https://www.ncbi.nlm.nih.gov/pubmed/32223157 http://dx.doi.org/10.1021/acs.jafc.0c00130

Ejemplares similares

Soybean- and Lupin-Derived Peptides Inhibit DPP-IV Activity on In Situ Human Intestinal Caco-2 Cells and Ex Vivo Human Serum
por: Lammi, Carmen, et al.
Publicado: (2018)

Trans-Epithelial Transport, Metabolism, and Biological Activity Assessment of the Multi-Target Lupin Peptide LILPKHSDAD (P5) and Its Metabolite LPKHSDAD (P5-Met)
por: Lammi, Carmen, et al.
Publicado: (2021)

Hypocholesterolaemic Activity of Lupin Peptides: Investigation on the Crosstalk between Human Enterocytes and Hepatocytes Using a Co-Culture System Including Caco-2 and HepG2 Cells
por: Lammi, Carmen, et al.
Publicado: (2016)

Analysis of Narrow-Leaf Lupin Proteins in Lupin-Enriched Pasta by Untargeted and Targeted Mass Spectrometry
por: Aiello, Gilda, et al.
Publicado: (2020)

Extra Virgin Olive Oil Phenolic Extract on Human Hepatic HepG2 and Intestinal Caco-2 Cells: Assessment of the Antioxidant Activity and Intestinal Trans-Epithelial Transport
por: Bartolomei, Martina, et al.
Publicado: (2021)

“Bottom-Up” Strategy for the Identification of Novel Soybean Peptides with Angiotensin-Converting Enzyme Inhibitory Activity
por: Dellafiora, Luca, et al.
Publicado: (2020)

Evaluation of the multifunctional dipeptidyl-peptidase IV and angiotensin converting enzyme inhibitory properties of a casein hydrolysate using cell-free and cell-based assays
por: Li, Jianqiang, et al.
Publicado: (2023)

Mechanistic Insights into Angiotensin I-Converting Enzyme Inhibitory Tripeptides to Decipher the Chemical Basis of Their Activity
por: Lammi, Carmen, et al.
Publicado: (2022)

Integrated Evaluation of the Multifunctional DPP-IV and ACE Inhibitory Effect of Soybean and Pea Protein Hydrolysates
por: Bollati, Carlotta, et al.
Publicado: (2022)

Lupin Peptides Modulate the Protein-Protein Interaction of PCSK9 with the Low Density Lipoprotein Receptor in HepG2 Cells
por: Lammi, Carmen, et al.
Publicado: (2016)

Lupin Peptide T9 (GQEQSHQDEGVIVR) Modulates the Mutant PCSK9(D374Y) Pathway: in vitro Characterization of its Dual Hypocholesterolemic Behavior
por: Lammi, Carmen, et al.
Publicado: (2019)

Gel-Forming of Self-Assembling Peptides Functionalized with Food Bioactive Motifs Modulate DPP-IV and ACE Inhibitory Activity in Human Intestinal Caco-2 Cells
por: Pugliese, Raffaele, et al.
Publicado: (2022)

Investigation of Chlorella pyrenoidosa Protein as a Source of Novel Angiotensin I-Converting Enzyme (ACE) and Dipeptidyl Peptidase-IV (DPP-IV) Inhibitory Peptides
por: Li, Yuchen, et al.
Publicado: (2021)

Phycobiliproteins from Arthrospira Platensis (Spirulina): A New Source of Peptides with Dipeptidyl Peptidase-IV Inhibitory Activity
por: Li, Yuchen, et al.
Publicado: (2020)

Rainbow Trout (Oncorhynchus mykiss) as Source of Multifunctional Peptides with Antioxidant, ACE and DPP-IV Inhibitory Activities
por: Bartolomei, Martina, et al.
Publicado: (2023)

Nanostructure, Self-Assembly, Mechanical Properties, and Antioxidant Activity of a Lupin-Derived Peptide Hydrogel
por: Pugliese, Raffaele, et al.
Publicado: (2021)

Nutraceutical Improvement Increases the Protective Activity of Broccoli Sprout Juice in a Human Intestinal Cell Model of Gut Inflammation
por: Ferruzza, Simonetta, et al.
Publicado: (2016)

Enhancement of the Stability and Anti-DPPIV Activity of Hempseed Hydrolysates Through Self-Assembling Peptide-Based Hydrogels
por: Lammi, Carmen, et al.
Publicado: (2019)

Assessment of the Physicochemical and Conformational Changes of Ultrasound-Driven Proteins Extracted from Soybean Okara Byproduct
por: Aiello, Gilda, et al.
Publicado: (2021)

Antioxidant Effect Assessment and Trans Epithelial Analysis of New Hempseed Protein Hydrolysates
por: Santos-Sánchez, Guillermo, et al.
Publicado: (2023)

Quality Assessment of the Protein Ingredients Recovered by Ultrasound-Assisted Extraction from the Press Cakes of Coconut and Almond Beverage Preparation
por: Aiello, Gilda, et al.
Publicado: (2022)

Computational Design and Biological Evaluation of Analogs of Lupin Peptide P5 Endowed with Dual PCSK9/HMG-CoAR Inhibiting Activity
por: Lammi, Carmen, et al.
Publicado: (2022)

Composition of the Protein Ingredients from Insoluble Oat Byproducts Treated with Food-Grade Enzymes, Such as Amylase, Cellulose/Xylanase, and Protease
por: Aiello, Gilda, et al.
Publicado: (2021)

Hempseed (Cannabis sativa) Peptide H3 (IGFLIIWV) Exerts Cholesterol-Lowering Effects in Human Hepatic Cell Line
por: Li, Jianqiang, et al.
Publicado: (2022)

Bioavailability Assessment of an Iron Formulation Using Differentiated Human Intestinal Caco-2 Cells
por: Fanzaga, Melissa, et al.
Publicado: (2023)

Exploitation of Olive (Olea europaea L.) Seed Proteins as Upgraded Source of Bioactive Peptides with Multifunctional Properties: Focus on Antioxidant and Dipeptidyl-Dipeptidase—IV Inhibitory Activities, and Glucagon-like Peptide 1 Improved Modulation
por: Bartolomei, Martina, et al.
Publicado: (2022)

Assessment of the Cholesterol-Lowering Effect of MOMAST(®): Biochemical and Cellular Studies
por: Bartolomei, Martina, et al.
Publicado: (2022)

Hempseed (Cannabis sativa) Peptides WVSPLAGRT and IGFLIIWV Exert Anti-inflammatory Activity in the LPS-Stimulated Human Hepatic Cell Line
por: Cruz-Chamorro, Ivan, et al.
Publicado: (2022)

An In Silico Framework to Mine Bioactive Peptides from Annotated Proteomes: A Case Study on Pancreatic Alpha Amylase Inhibitory Peptides from Algae and Cyanobacteria
por: Pedroni, Lorenzo, et al.
Publicado: (2022)

Preparation, Characterization and In Vitro Stability of a Novel ACE-Inhibitory Peptide from Soybean Protein
por: Sangiorgio, Sara, et al.
Publicado: (2022)

Lupin-Derived Bioactive Peptides: Intestinal Transport, Bioavailability and Health Benefits
por: Okagu, Innocent U., et al.
Publicado: (2021)

Toxicodynamics of Mycotoxins in the Framework of Food Risk Assessment—An In Silico Perspective
por: Dellafiora, Luca, et al.
Publicado: (2018)

In Silico Approaches Applied to the Study of Peptide Analogs of Ile-Pro-Ile in Relation to Their Dipeptidyl Peptidase IV Inhibitory Properties
por: Nongonierma, Alice B., et al.
Publicado: (2018)

Degradation of Aflatoxins by Means of Laccases from Trametes versicolor: An In Silico Insight
por: Dellafiora, Luca, et al.
Publicado: (2017)

Simulated Gastrointestinal Digestion of Cocoa: Detection of Resistant Peptides and In Silico/In Vitro Prediction of Their Ace Inhibitory Activity
por: Marseglia, Angela, et al.
Publicado: (2019)

Phenolic Extracts from Extra Virgin Olive Oils Inhibit Dipeptidyl Peptidase IV Activity: In Vitro, Cellular, and In Silico Molecular Modeling Investigations
por: Lammi, Carmen, et al.
Publicado: (2021)

On the Mechanism of Action of Anti-Inflammatory Activity of Hypericin: An In Silico Study Pointing to the Relevance of Janus Kinases Inhibition
por: Dellafiora, Luca, et al.
Publicado: (2018)

In silico study on the Hepatitis E virus RNA Helicase and its inhibition by silvestrol, rocaglamide and other flavagline compounds
por: Pedroni, Lorenzo, et al.
Publicado: (2022)

Three Peptides from Soy Glycinin Modulate Glucose Metabolism in Human Hepatic HepG2 Cells
por: Lammi, Carmen, et al.
Publicado: (2015)

Extra Virgin Olive Oil Phenol Extracts Exert Hypocholesterolemic Effects through the Modulation of the LDLR Pathway: In Vitro and Cellular Mechanism of Action Elucidation
por: Lammi, Carmen, et al.
Publicado: (2020)

Cannot write session to /tmp/vufind_sessions/sess_3td73a0ijk7jkr15aurr2094oh