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Targeted design of drug binding sites in the main protease of SARS-CoV-2 reveals potential signatures of adaptation
Several existing drugs are currently being tested worldwide to treat COVID-19 patients. Recent data indicate that SARS-CoV-2 is rapidly evolving into more transmissible variants. It is therefore highly possible that SARS-CoV-2 can accumulate adaptive mutations modulating drug susceptibility and hamp...
| Autores principales: | , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Elsevier Inc.
2021
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7997393/ https://www.ncbi.nlm.nih.gov/pubmed/33813274 http://dx.doi.org/10.1016/j.bbrc.2021.03.118 |