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Prognostic Role of CSF β-amyloid 1–42/1–40 Ratio in Patients Affected by Amyotrophic Lateral Sclerosis
The involvement of β-amyloid (Aβ) in the pathogenesis of amyotrophic lateral sclerosis (ALS) has been widely discussed and its role in the disease is still a matter of debate. Aβ accumulates in the cortex and the anterior horn neurons of ALS patients and seems to affect their survival. To clarify th...
Autores principales: | , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7997395/ https://www.ncbi.nlm.nih.gov/pubmed/33673569 http://dx.doi.org/10.3390/brainsci11030302 |
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author | Colletti, Tiziana Agnello, Luisa Spataro, Rossella Guccione, Lavinia Notaro, Antonietta Lo Sasso, Bruna Blandino, Valeria Graziano, Fabiola Gambino, Caterina Maria Giglio, Rosaria Vincenza Bivona, Giulia La Bella, Vincenzo Ciaccio, Marcello Piccoli, Tommaso |
author_facet | Colletti, Tiziana Agnello, Luisa Spataro, Rossella Guccione, Lavinia Notaro, Antonietta Lo Sasso, Bruna Blandino, Valeria Graziano, Fabiola Gambino, Caterina Maria Giglio, Rosaria Vincenza Bivona, Giulia La Bella, Vincenzo Ciaccio, Marcello Piccoli, Tommaso |
author_sort | Colletti, Tiziana |
collection | PubMed |
description | The involvement of β-amyloid (Aβ) in the pathogenesis of amyotrophic lateral sclerosis (ALS) has been widely discussed and its role in the disease is still a matter of debate. Aβ accumulates in the cortex and the anterior horn neurons of ALS patients and seems to affect their survival. To clarify the role of cerebrospinal fluid (CSF) Aβ 1–42 and Aβ 42/40 ratios as a potential prognostic biomarker for ALS, we performed a retrospective observational study on a cohort of ALS patients who underwent a lumbar puncture at the time of the diagnosis. CSF Aβ 1–40 and Aβ 1–42 ratios were detected by chemiluminescence immunoassay and their values were correlated with clinical features. We found a significant correlation of the Aβ 42/40 ratio with age at onset and Mini Mental State Examination (MMSE) scores. No significant correlation of Aβ 1–42 or Aβ 42/40 ratios to the rate of progression of the disease were found. Furthermore, when we stratified patients according to Aβ 1–42 concentration and the Aβ 42/40 ratio, we found that patients with a lower Aβ 42/40 ratio showed a shorter survival. Our results support the hypothesis that Aβ 1–42 could be involved in some pathogenic mechanism of ALS and we suggest the Aβ 42/40 ratio as a potential prognostic biomarker. |
format | Online Article Text |
id | pubmed-7997395 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-79973952021-03-27 Prognostic Role of CSF β-amyloid 1–42/1–40 Ratio in Patients Affected by Amyotrophic Lateral Sclerosis Colletti, Tiziana Agnello, Luisa Spataro, Rossella Guccione, Lavinia Notaro, Antonietta Lo Sasso, Bruna Blandino, Valeria Graziano, Fabiola Gambino, Caterina Maria Giglio, Rosaria Vincenza Bivona, Giulia La Bella, Vincenzo Ciaccio, Marcello Piccoli, Tommaso Brain Sci Article The involvement of β-amyloid (Aβ) in the pathogenesis of amyotrophic lateral sclerosis (ALS) has been widely discussed and its role in the disease is still a matter of debate. Aβ accumulates in the cortex and the anterior horn neurons of ALS patients and seems to affect their survival. To clarify the role of cerebrospinal fluid (CSF) Aβ 1–42 and Aβ 42/40 ratios as a potential prognostic biomarker for ALS, we performed a retrospective observational study on a cohort of ALS patients who underwent a lumbar puncture at the time of the diagnosis. CSF Aβ 1–40 and Aβ 1–42 ratios were detected by chemiluminescence immunoassay and their values were correlated with clinical features. We found a significant correlation of the Aβ 42/40 ratio with age at onset and Mini Mental State Examination (MMSE) scores. No significant correlation of Aβ 1–42 or Aβ 42/40 ratios to the rate of progression of the disease were found. Furthermore, when we stratified patients according to Aβ 1–42 concentration and the Aβ 42/40 ratio, we found that patients with a lower Aβ 42/40 ratio showed a shorter survival. Our results support the hypothesis that Aβ 1–42 could be involved in some pathogenic mechanism of ALS and we suggest the Aβ 42/40 ratio as a potential prognostic biomarker. MDPI 2021-02-27 /pmc/articles/PMC7997395/ /pubmed/33673569 http://dx.doi.org/10.3390/brainsci11030302 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) ). |
spellingShingle | Article Colletti, Tiziana Agnello, Luisa Spataro, Rossella Guccione, Lavinia Notaro, Antonietta Lo Sasso, Bruna Blandino, Valeria Graziano, Fabiola Gambino, Caterina Maria Giglio, Rosaria Vincenza Bivona, Giulia La Bella, Vincenzo Ciaccio, Marcello Piccoli, Tommaso Prognostic Role of CSF β-amyloid 1–42/1–40 Ratio in Patients Affected by Amyotrophic Lateral Sclerosis |
title | Prognostic Role of CSF β-amyloid 1–42/1–40 Ratio in Patients Affected by Amyotrophic Lateral Sclerosis |
title_full | Prognostic Role of CSF β-amyloid 1–42/1–40 Ratio in Patients Affected by Amyotrophic Lateral Sclerosis |
title_fullStr | Prognostic Role of CSF β-amyloid 1–42/1–40 Ratio in Patients Affected by Amyotrophic Lateral Sclerosis |
title_full_unstemmed | Prognostic Role of CSF β-amyloid 1–42/1–40 Ratio in Patients Affected by Amyotrophic Lateral Sclerosis |
title_short | Prognostic Role of CSF β-amyloid 1–42/1–40 Ratio in Patients Affected by Amyotrophic Lateral Sclerosis |
title_sort | prognostic role of csf β-amyloid 1–42/1–40 ratio in patients affected by amyotrophic lateral sclerosis |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7997395/ https://www.ncbi.nlm.nih.gov/pubmed/33673569 http://dx.doi.org/10.3390/brainsci11030302 |
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