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Prognostic Role of CSF β-amyloid 1–42/1–40 Ratio in Patients Affected by Amyotrophic Lateral Sclerosis

The involvement of β-amyloid (Aβ) in the pathogenesis of amyotrophic lateral sclerosis (ALS) has been widely discussed and its role in the disease is still a matter of debate. Aβ accumulates in the cortex and the anterior horn neurons of ALS patients and seems to affect their survival. To clarify th...

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Autores principales: Colletti, Tiziana, Agnello, Luisa, Spataro, Rossella, Guccione, Lavinia, Notaro, Antonietta, Lo Sasso, Bruna, Blandino, Valeria, Graziano, Fabiola, Gambino, Caterina Maria, Giglio, Rosaria Vincenza, Bivona, Giulia, La Bella, Vincenzo, Ciaccio, Marcello, Piccoli, Tommaso
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7997395/
https://www.ncbi.nlm.nih.gov/pubmed/33673569
http://dx.doi.org/10.3390/brainsci11030302
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author Colletti, Tiziana
Agnello, Luisa
Spataro, Rossella
Guccione, Lavinia
Notaro, Antonietta
Lo Sasso, Bruna
Blandino, Valeria
Graziano, Fabiola
Gambino, Caterina Maria
Giglio, Rosaria Vincenza
Bivona, Giulia
La Bella, Vincenzo
Ciaccio, Marcello
Piccoli, Tommaso
author_facet Colletti, Tiziana
Agnello, Luisa
Spataro, Rossella
Guccione, Lavinia
Notaro, Antonietta
Lo Sasso, Bruna
Blandino, Valeria
Graziano, Fabiola
Gambino, Caterina Maria
Giglio, Rosaria Vincenza
Bivona, Giulia
La Bella, Vincenzo
Ciaccio, Marcello
Piccoli, Tommaso
author_sort Colletti, Tiziana
collection PubMed
description The involvement of β-amyloid (Aβ) in the pathogenesis of amyotrophic lateral sclerosis (ALS) has been widely discussed and its role in the disease is still a matter of debate. Aβ accumulates in the cortex and the anterior horn neurons of ALS patients and seems to affect their survival. To clarify the role of cerebrospinal fluid (CSF) Aβ 1–42 and Aβ 42/40 ratios as a potential prognostic biomarker for ALS, we performed a retrospective observational study on a cohort of ALS patients who underwent a lumbar puncture at the time of the diagnosis. CSF Aβ 1–40 and Aβ 1–42 ratios were detected by chemiluminescence immunoassay and their values were correlated with clinical features. We found a significant correlation of the Aβ 42/40 ratio with age at onset and Mini Mental State Examination (MMSE) scores. No significant correlation of Aβ 1–42 or Aβ 42/40 ratios to the rate of progression of the disease were found. Furthermore, when we stratified patients according to Aβ 1–42 concentration and the Aβ 42/40 ratio, we found that patients with a lower Aβ 42/40 ratio showed a shorter survival. Our results support the hypothesis that Aβ 1–42 could be involved in some pathogenic mechanism of ALS and we suggest the Aβ 42/40 ratio as a potential prognostic biomarker.
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spelling pubmed-79973952021-03-27 Prognostic Role of CSF β-amyloid 1–42/1–40 Ratio in Patients Affected by Amyotrophic Lateral Sclerosis Colletti, Tiziana Agnello, Luisa Spataro, Rossella Guccione, Lavinia Notaro, Antonietta Lo Sasso, Bruna Blandino, Valeria Graziano, Fabiola Gambino, Caterina Maria Giglio, Rosaria Vincenza Bivona, Giulia La Bella, Vincenzo Ciaccio, Marcello Piccoli, Tommaso Brain Sci Article The involvement of β-amyloid (Aβ) in the pathogenesis of amyotrophic lateral sclerosis (ALS) has been widely discussed and its role in the disease is still a matter of debate. Aβ accumulates in the cortex and the anterior horn neurons of ALS patients and seems to affect their survival. To clarify the role of cerebrospinal fluid (CSF) Aβ 1–42 and Aβ 42/40 ratios as a potential prognostic biomarker for ALS, we performed a retrospective observational study on a cohort of ALS patients who underwent a lumbar puncture at the time of the diagnosis. CSF Aβ 1–40 and Aβ 1–42 ratios were detected by chemiluminescence immunoassay and their values were correlated with clinical features. We found a significant correlation of the Aβ 42/40 ratio with age at onset and Mini Mental State Examination (MMSE) scores. No significant correlation of Aβ 1–42 or Aβ 42/40 ratios to the rate of progression of the disease were found. Furthermore, when we stratified patients according to Aβ 1–42 concentration and the Aβ 42/40 ratio, we found that patients with a lower Aβ 42/40 ratio showed a shorter survival. Our results support the hypothesis that Aβ 1–42 could be involved in some pathogenic mechanism of ALS and we suggest the Aβ 42/40 ratio as a potential prognostic biomarker. MDPI 2021-02-27 /pmc/articles/PMC7997395/ /pubmed/33673569 http://dx.doi.org/10.3390/brainsci11030302 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) ).
spellingShingle Article
Colletti, Tiziana
Agnello, Luisa
Spataro, Rossella
Guccione, Lavinia
Notaro, Antonietta
Lo Sasso, Bruna
Blandino, Valeria
Graziano, Fabiola
Gambino, Caterina Maria
Giglio, Rosaria Vincenza
Bivona, Giulia
La Bella, Vincenzo
Ciaccio, Marcello
Piccoli, Tommaso
Prognostic Role of CSF β-amyloid 1–42/1–40 Ratio in Patients Affected by Amyotrophic Lateral Sclerosis
title Prognostic Role of CSF β-amyloid 1–42/1–40 Ratio in Patients Affected by Amyotrophic Lateral Sclerosis
title_full Prognostic Role of CSF β-amyloid 1–42/1–40 Ratio in Patients Affected by Amyotrophic Lateral Sclerosis
title_fullStr Prognostic Role of CSF β-amyloid 1–42/1–40 Ratio in Patients Affected by Amyotrophic Lateral Sclerosis
title_full_unstemmed Prognostic Role of CSF β-amyloid 1–42/1–40 Ratio in Patients Affected by Amyotrophic Lateral Sclerosis
title_short Prognostic Role of CSF β-amyloid 1–42/1–40 Ratio in Patients Affected by Amyotrophic Lateral Sclerosis
title_sort prognostic role of csf β-amyloid 1–42/1–40 ratio in patients affected by amyotrophic lateral sclerosis
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7997395/
https://www.ncbi.nlm.nih.gov/pubmed/33673569
http://dx.doi.org/10.3390/brainsci11030302
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