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Retrospective Evaluation of Progenitor Biological Bandage Use: A Complementary and Safe Therapeutic Management Option for Prevention of Hypertrophic Scarring in Pediatric Burn Care

Progenitor Biological Bandages (PBB) have been continuously applied clinically in the Lausanne Burn Center for over two decades. Vast translational experience and hindsight have been gathered, specifically for cutaneous healing promotion of donor-site grafts and second-degree pediatric burns. PBBs c...

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Autores principales: Al-Dourobi, Karim, Laurent, Alexis, Deghayli, Lina, Flahaut, Marjorie, Abdel-Sayed, Philippe, Scaletta, Corinne, Michetti, Murielle, Waselle, Laurent, Simon, Jeanne-Pascale, El Ezzi, Oumama, Raffoul, Wassim, Applegate, Lee Ann, Hirt-Burri, Nathalie, Roessingh, Anthony S de Buys
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7997469/
https://www.ncbi.nlm.nih.gov/pubmed/33671009
http://dx.doi.org/10.3390/ph14030201
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author Al-Dourobi, Karim
Laurent, Alexis
Deghayli, Lina
Flahaut, Marjorie
Abdel-Sayed, Philippe
Scaletta, Corinne
Michetti, Murielle
Waselle, Laurent
Simon, Jeanne-Pascale
El Ezzi, Oumama
Raffoul, Wassim
Applegate, Lee Ann
Hirt-Burri, Nathalie
Roessingh, Anthony S de Buys
author_facet Al-Dourobi, Karim
Laurent, Alexis
Deghayli, Lina
Flahaut, Marjorie
Abdel-Sayed, Philippe
Scaletta, Corinne
Michetti, Murielle
Waselle, Laurent
Simon, Jeanne-Pascale
El Ezzi, Oumama
Raffoul, Wassim
Applegate, Lee Ann
Hirt-Burri, Nathalie
Roessingh, Anthony S de Buys
author_sort Al-Dourobi, Karim
collection PubMed
description Progenitor Biological Bandages (PBB) have been continuously applied clinically in the Lausanne Burn Center for over two decades. Vast translational experience and hindsight have been gathered, specifically for cutaneous healing promotion of donor-site grafts and second-degree pediatric burns. PBBs constitute combined Advanced Therapy Medicinal Products, containing viable cultured allogeneic fetal dermal progenitor fibroblasts. Such constructs may partly favor repair and regeneration of functional cutaneous tissues by releasing cytokines and growth factors, potentially negating the need for subsequent skin grafting, while reducing the formation of hypertrophic scar tissues. This retrospective case-control study (2010–2018) of pediatric second-degree burn patients comprehensively compared two initial wound treatment options (i.e., PBBs versus Aquacel(®) Ag, applied during ten to twelve days post-trauma). Results confirmed clinical safety of PBBs with regard to morbidity, mortality, and overall complications. No difference was detected between groups for length of hospitalization or initial relative burn surface decreasing rates. Nevertheless, a trend was observed in younger patients treated with PBBs, requiring fewer corrective interventions or subsequent skin grafting. Importantly, significant improvements were observed in the PBB group regarding hypertrophic scarring (i.e., reduced number of scar complications and related corrective interventions). Such results establish evidence of clinical benefits yielded by the Swiss fetal progenitor cell transplantation program and favor further implementation of specific cell therapies in highly specialized regenerative medicine.
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spelling pubmed-79974692021-03-27 Retrospective Evaluation of Progenitor Biological Bandage Use: A Complementary and Safe Therapeutic Management Option for Prevention of Hypertrophic Scarring in Pediatric Burn Care Al-Dourobi, Karim Laurent, Alexis Deghayli, Lina Flahaut, Marjorie Abdel-Sayed, Philippe Scaletta, Corinne Michetti, Murielle Waselle, Laurent Simon, Jeanne-Pascale El Ezzi, Oumama Raffoul, Wassim Applegate, Lee Ann Hirt-Burri, Nathalie Roessingh, Anthony S de Buys Pharmaceuticals (Basel) Article Progenitor Biological Bandages (PBB) have been continuously applied clinically in the Lausanne Burn Center for over two decades. Vast translational experience and hindsight have been gathered, specifically for cutaneous healing promotion of donor-site grafts and second-degree pediatric burns. PBBs constitute combined Advanced Therapy Medicinal Products, containing viable cultured allogeneic fetal dermal progenitor fibroblasts. Such constructs may partly favor repair and regeneration of functional cutaneous tissues by releasing cytokines and growth factors, potentially negating the need for subsequent skin grafting, while reducing the formation of hypertrophic scar tissues. This retrospective case-control study (2010–2018) of pediatric second-degree burn patients comprehensively compared two initial wound treatment options (i.e., PBBs versus Aquacel(®) Ag, applied during ten to twelve days post-trauma). Results confirmed clinical safety of PBBs with regard to morbidity, mortality, and overall complications. No difference was detected between groups for length of hospitalization or initial relative burn surface decreasing rates. Nevertheless, a trend was observed in younger patients treated with PBBs, requiring fewer corrective interventions or subsequent skin grafting. Importantly, significant improvements were observed in the PBB group regarding hypertrophic scarring (i.e., reduced number of scar complications and related corrective interventions). Such results establish evidence of clinical benefits yielded by the Swiss fetal progenitor cell transplantation program and favor further implementation of specific cell therapies in highly specialized regenerative medicine. MDPI 2021-02-28 /pmc/articles/PMC7997469/ /pubmed/33671009 http://dx.doi.org/10.3390/ph14030201 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) ).
spellingShingle Article
Al-Dourobi, Karim
Laurent, Alexis
Deghayli, Lina
Flahaut, Marjorie
Abdel-Sayed, Philippe
Scaletta, Corinne
Michetti, Murielle
Waselle, Laurent
Simon, Jeanne-Pascale
El Ezzi, Oumama
Raffoul, Wassim
Applegate, Lee Ann
Hirt-Burri, Nathalie
Roessingh, Anthony S de Buys
Retrospective Evaluation of Progenitor Biological Bandage Use: A Complementary and Safe Therapeutic Management Option for Prevention of Hypertrophic Scarring in Pediatric Burn Care
title Retrospective Evaluation of Progenitor Biological Bandage Use: A Complementary and Safe Therapeutic Management Option for Prevention of Hypertrophic Scarring in Pediatric Burn Care
title_full Retrospective Evaluation of Progenitor Biological Bandage Use: A Complementary and Safe Therapeutic Management Option for Prevention of Hypertrophic Scarring in Pediatric Burn Care
title_fullStr Retrospective Evaluation of Progenitor Biological Bandage Use: A Complementary and Safe Therapeutic Management Option for Prevention of Hypertrophic Scarring in Pediatric Burn Care
title_full_unstemmed Retrospective Evaluation of Progenitor Biological Bandage Use: A Complementary and Safe Therapeutic Management Option for Prevention of Hypertrophic Scarring in Pediatric Burn Care
title_short Retrospective Evaluation of Progenitor Biological Bandage Use: A Complementary and Safe Therapeutic Management Option for Prevention of Hypertrophic Scarring in Pediatric Burn Care
title_sort retrospective evaluation of progenitor biological bandage use: a complementary and safe therapeutic management option for prevention of hypertrophic scarring in pediatric burn care
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7997469/
https://www.ncbi.nlm.nih.gov/pubmed/33671009
http://dx.doi.org/10.3390/ph14030201
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