Loss of Ftsj1 perturbs codon-specific translation efficiency in the brain and is associated with X-linked intellectual disability

FtsJ RNA 2′-O-methyltransferase 1 (FTSJ1) gene has been implicated in X-linked intellectual disability (XLID), but the molecular pathogenesis is unknown. We show that Ftsj1 is responsible for 2′-O-methylation of 11 species of cytosolic transfer RNAs (tRNAs) at the anticodon region, and these modific...

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Detalles Bibliográficos
Autores principales: Nagayoshi, Y., Chujo, T., Hirata, S., Nakatsuka, H., Chen, C.-W., Takakura, M., Miyauchi, K., Ikeuchi, Y., Carlyle, B. C., Kitchen, R. R., Suzuki, T., Katsuoka, F., Yamamoto, M., Goto, Y., Tanaka, M., Natsume, K., Nairn, A. C., Tomizawa, K., Wei, F.-Y.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for the Advancement of Science 2021
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7997516/
https://www.ncbi.nlm.nih.gov/pubmed/33771871
http://dx.doi.org/10.1126/sciadv.abf3072

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