Cell-penetrating Alphabody protein scaffolds for intracellular drug targeting

The therapeutic scope of antibody and nonantibody protein scaffolds is still prohibitively limited against intracellular drug targets. Here, we demonstrate that the Alphabody scaffold can be engineered into a cell-penetrating protein antagonist against induced myeloid leukemia cell differentiation p...

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Detalles Bibliográficos
Autores principales: Pannecoucke, Erwin, Van Trimpont, Maaike, Desmet, Johan, Pieters, Tim, Reunes, Lindy, Demoen, Lisa, Vuylsteke, Marnik, Loverix, Stefan, Vandenbroucke, Karen, Alard, Philippe, Henderikx, Paula, Deroo, Sabrina, Baatz, Franky, Lorent, Eric, Thiolloy, Sophie, Somers, Klaartje, McGrath, Yvonne, Vlierberghe, Pieter Van, Lasters, Ignace, Savvides, Savvas N.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for the Advancement of Science 2021
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7997521/
https://www.ncbi.nlm.nih.gov/pubmed/33771865
http://dx.doi.org/10.1126/sciadv.abe1682

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