Light-Triggered Catalytic Asymmetric Allylic Benzylation with Photogenerated C-Nucleophiles

[Image: see text] Herein is reported the asymmetric allylic benzylation of Morita–Baylis–Hillman (MBH) carbonates with 2-methylbenzophenone (MBP) derivatives as nonstabilized photogenerated C-nucleophiles. The dual activation of both reaction partners, chiral Lewis-base activation of the electrophil...

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Detalles Bibliográficos
Autores principales: Paria, Suva, Carletti, Edoardo, Marcon, Michela, Cherubini-Celli, Alessio, Mazzanti, Andrea, Rancan, Marzio, Dell’Amico, Luca, Bonchio, Marcella, Companyó, Xavier
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2020
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7997570/
https://www.ncbi.nlm.nih.gov/pubmed/32081000
http://dx.doi.org/10.1021/acs.joc.0c00175
Descripción
Sumario:[Image: see text] Herein is reported the asymmetric allylic benzylation of Morita–Baylis–Hillman (MBH) carbonates with 2-methylbenzophenone (MBP) derivatives as nonstabilized photogenerated C-nucleophiles. The dual activation of both reaction partners, chiral Lewis-base activation of the electrophile and light activation of the nucleophile, enables the stereoselective installation of benzyl groups at the allylic position to forge tertiary and quaternary carbon centers.

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