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Thiazoles, Their Benzofused Systems, and Thiazolidinone Derivatives: Versatile and Promising Tools to Combat Antibiotic Resistance
[Image: see text] Thiazoles, their benzofused systems, and thiazolidinone derivatives are widely recognized as nuclei of great value for obtaining molecules with various biological activities, including analgesic, anti-inflammatory, anti-HIV, antidiabetic, antitumor, and antimicrobial. In particular...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
American Chemical
Society
2020
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7997583/ https://www.ncbi.nlm.nih.gov/pubmed/32208685 http://dx.doi.org/10.1021/acs.jmedchem.9b01245 |
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author | Cascioferro, Stella Parrino, Barbara Carbone, Daniela Schillaci, Domenico Giovannetti, Elisa Cirrincione, Girolamo Diana, Patrizia |
author_facet | Cascioferro, Stella Parrino, Barbara Carbone, Daniela Schillaci, Domenico Giovannetti, Elisa Cirrincione, Girolamo Diana, Patrizia |
author_sort | Cascioferro, Stella |
collection | PubMed |
description | [Image: see text] Thiazoles, their benzofused systems, and thiazolidinone derivatives are widely recognized as nuclei of great value for obtaining molecules with various biological activities, including analgesic, anti-inflammatory, anti-HIV, antidiabetic, antitumor, and antimicrobial. In particular, in the past decade, many compounds bearing these heterocycles have been studied for their promising antibacterial properties due to their action on different microbial targets. Here we assess the recent development of this class of compounds to address mechanisms underlying antibiotic resistance at both bacterial-cell and community levels (biofilms). We also explore the SAR and the prospective clinical application of thiazole and its benzofused derivatives, which act as inhibitors of mechanisms underlying antibiotic resistance in the treatment of severe drug-resistant infections. In addition, we examined all bacterial targets involved in their antimicrobial activity reporting, when described, their spontaneous frequencies of resistance. |
format | Online Article Text |
id | pubmed-7997583 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | American Chemical
Society |
record_format | MEDLINE/PubMed |
spelling | pubmed-79975832021-03-29 Thiazoles, Their Benzofused Systems, and Thiazolidinone Derivatives: Versatile and Promising Tools to Combat Antibiotic Resistance Cascioferro, Stella Parrino, Barbara Carbone, Daniela Schillaci, Domenico Giovannetti, Elisa Cirrincione, Girolamo Diana, Patrizia J Med Chem [Image: see text] Thiazoles, their benzofused systems, and thiazolidinone derivatives are widely recognized as nuclei of great value for obtaining molecules with various biological activities, including analgesic, anti-inflammatory, anti-HIV, antidiabetic, antitumor, and antimicrobial. In particular, in the past decade, many compounds bearing these heterocycles have been studied for their promising antibacterial properties due to their action on different microbial targets. Here we assess the recent development of this class of compounds to address mechanisms underlying antibiotic resistance at both bacterial-cell and community levels (biofilms). We also explore the SAR and the prospective clinical application of thiazole and its benzofused derivatives, which act as inhibitors of mechanisms underlying antibiotic resistance in the treatment of severe drug-resistant infections. In addition, we examined all bacterial targets involved in their antimicrobial activity reporting, when described, their spontaneous frequencies of resistance. American Chemical Society 2020-03-25 2020-08-13 /pmc/articles/PMC7997583/ /pubmed/32208685 http://dx.doi.org/10.1021/acs.jmedchem.9b01245 Text en Permits the broadest form of re-use including for commercial purposes, provided that author attribution and integrity are maintained (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Cascioferro, Stella Parrino, Barbara Carbone, Daniela Schillaci, Domenico Giovannetti, Elisa Cirrincione, Girolamo Diana, Patrizia Thiazoles, Their Benzofused Systems, and Thiazolidinone Derivatives: Versatile and Promising Tools to Combat Antibiotic Resistance |
title | Thiazoles, Their
Benzofused Systems, and Thiazolidinone
Derivatives: Versatile and Promising Tools to Combat Antibiotic Resistance |
title_full | Thiazoles, Their
Benzofused Systems, and Thiazolidinone
Derivatives: Versatile and Promising Tools to Combat Antibiotic Resistance |
title_fullStr | Thiazoles, Their
Benzofused Systems, and Thiazolidinone
Derivatives: Versatile and Promising Tools to Combat Antibiotic Resistance |
title_full_unstemmed | Thiazoles, Their
Benzofused Systems, and Thiazolidinone
Derivatives: Versatile and Promising Tools to Combat Antibiotic Resistance |
title_short | Thiazoles, Their
Benzofused Systems, and Thiazolidinone
Derivatives: Versatile and Promising Tools to Combat Antibiotic Resistance |
title_sort | thiazoles, their
benzofused systems, and thiazolidinone
derivatives: versatile and promising tools to combat antibiotic resistance |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7997583/ https://www.ncbi.nlm.nih.gov/pubmed/32208685 http://dx.doi.org/10.1021/acs.jmedchem.9b01245 |
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