Antioxidant Activity of Compounds Isolated from Elaeagnus umbellata Promotes Human Gingival Fibroblast Well-Being

[Image: see text] Four new triterpenoid bidesmosidic saponins (1–4) and a sesquiterpenoid glucoside (5), together with nine known phenolic compounds (6–14), were isolated from the fruits of Elaeagnus umbellata. Their structures were elucidated using 1D and 2D NMR spectroscopy and mass spectrometry d...

Descripción completa

Detalles Bibliográficos
Autores principales: Iannuzzi, Anna Maria, Giacomelli, Chiara, De Leo, Marinella, Pietrobono, Deborah, Camangi, Fabiano, De Tommasi, Nunziatina, Martini, Claudia, Trincavelli, Maria Letizia, Braca, Alessandra
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society and American Society of Pharmacognosy 2020
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7997630/
https://www.ncbi.nlm.nih.gov/pubmed/32031808
http://dx.doi.org/10.1021/acs.jnatprod.9b01030
Descripción
Sumario:[Image: see text] Four new triterpenoid bidesmosidic saponins (1–4) and a sesquiterpenoid glucoside (5), together with nine known phenolic compounds (6–14), were isolated from the fruits of Elaeagnus umbellata. Their structures were elucidated using 1D and 2D NMR spectroscopy and mass spectrometry data. The antioxidant capability of the isolated compounds was evaluated in human gingival fibroblasts. Compound 6 decreased ROS production and promoted cell proliferation. It also counteracted the cell cycle blockade induced by a low concentration of H(2)O(2) decreasing the expression of p21 and CDKN2A (p16(INK4A)). Compound 6 decreased the expression of inflammatory cytokines (IL-6 and IL-8) in response to inflammatory stimuli, supporting its possible use in periodontitis lesions.

Ejemplares similares