Antioxidant Activity of Compounds Isolated from Elaeagnus umbellata Promotes Human Gingival Fibroblast Well-Being

[Image: see text] Four new triterpenoid bidesmosidic saponins (1–4) and a sesquiterpenoid glucoside (5), together with nine known phenolic compounds (6–14), were isolated from the fruits of Elaeagnus umbellata. Their structures were elucidated using 1D and 2D NMR spectroscopy and mass spectrometry d...

Descripción completa

Detalles Bibliográficos
Autores principales: Iannuzzi, Anna Maria, Giacomelli, Chiara, De Leo, Marinella, Pietrobono, Deborah, Camangi, Fabiano, De Tommasi, Nunziatina, Martini, Claudia, Trincavelli, Maria Letizia, Braca, Alessandra
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society and American Society of Pharmacognosy 2020
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7997630/
https://www.ncbi.nlm.nih.gov/pubmed/32031808
http://dx.doi.org/10.1021/acs.jnatprod.9b01030
_version_ 1783670372195893248
author Iannuzzi, Anna Maria
Giacomelli, Chiara
De Leo, Marinella
Pietrobono, Deborah
Camangi, Fabiano
De Tommasi, Nunziatina
Martini, Claudia
Trincavelli, Maria Letizia
Braca, Alessandra
author_facet Iannuzzi, Anna Maria
Giacomelli, Chiara
De Leo, Marinella
Pietrobono, Deborah
Camangi, Fabiano
De Tommasi, Nunziatina
Martini, Claudia
Trincavelli, Maria Letizia
Braca, Alessandra
author_sort Iannuzzi, Anna Maria
collection PubMed
description [Image: see text] Four new triterpenoid bidesmosidic saponins (1–4) and a sesquiterpenoid glucoside (5), together with nine known phenolic compounds (6–14), were isolated from the fruits of Elaeagnus umbellata. Their structures were elucidated using 1D and 2D NMR spectroscopy and mass spectrometry data. The antioxidant capability of the isolated compounds was evaluated in human gingival fibroblasts. Compound 6 decreased ROS production and promoted cell proliferation. It also counteracted the cell cycle blockade induced by a low concentration of H(2)O(2) decreasing the expression of p21 and CDKN2A (p16(INK4A)). Compound 6 decreased the expression of inflammatory cytokines (IL-6 and IL-8) in response to inflammatory stimuli, supporting its possible use in periodontitis lesions.
format Online
Article
Text
id pubmed-7997630
institution National Center for Biotechnology Information
language English
publishDate 2020
publisher American Chemical Society and American Society of Pharmacognosy
record_format MEDLINE/PubMed
spelling pubmed-79976302021-03-29 Antioxidant Activity of Compounds Isolated from Elaeagnus umbellata Promotes Human Gingival Fibroblast Well-Being Iannuzzi, Anna Maria Giacomelli, Chiara De Leo, Marinella Pietrobono, Deborah Camangi, Fabiano De Tommasi, Nunziatina Martini, Claudia Trincavelli, Maria Letizia Braca, Alessandra J Nat Prod [Image: see text] Four new triterpenoid bidesmosidic saponins (1–4) and a sesquiterpenoid glucoside (5), together with nine known phenolic compounds (6–14), were isolated from the fruits of Elaeagnus umbellata. Their structures were elucidated using 1D and 2D NMR spectroscopy and mass spectrometry data. The antioxidant capability of the isolated compounds was evaluated in human gingival fibroblasts. Compound 6 decreased ROS production and promoted cell proliferation. It also counteracted the cell cycle blockade induced by a low concentration of H(2)O(2) decreasing the expression of p21 and CDKN2A (p16(INK4A)). Compound 6 decreased the expression of inflammatory cytokines (IL-6 and IL-8) in response to inflammatory stimuli, supporting its possible use in periodontitis lesions. American Chemical Society and American Society of Pharmacognosy 2020-02-07 2020-03-27 /pmc/articles/PMC7997630/ /pubmed/32031808 http://dx.doi.org/10.1021/acs.jnatprod.9b01030 Text en Permits the broadest form of re-use including for commercial purposes, provided that author attribution and integrity are maintained (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Iannuzzi, Anna Maria
Giacomelli, Chiara
De Leo, Marinella
Pietrobono, Deborah
Camangi, Fabiano
De Tommasi, Nunziatina
Martini, Claudia
Trincavelli, Maria Letizia
Braca, Alessandra
Antioxidant Activity of Compounds Isolated from Elaeagnus umbellata Promotes Human Gingival Fibroblast Well-Being
title Antioxidant Activity of Compounds Isolated from Elaeagnus umbellata Promotes Human Gingival Fibroblast Well-Being
title_full Antioxidant Activity of Compounds Isolated from Elaeagnus umbellata Promotes Human Gingival Fibroblast Well-Being
title_fullStr Antioxidant Activity of Compounds Isolated from Elaeagnus umbellata Promotes Human Gingival Fibroblast Well-Being
title_full_unstemmed Antioxidant Activity of Compounds Isolated from Elaeagnus umbellata Promotes Human Gingival Fibroblast Well-Being
title_short Antioxidant Activity of Compounds Isolated from Elaeagnus umbellata Promotes Human Gingival Fibroblast Well-Being
title_sort antioxidant activity of compounds isolated from elaeagnus umbellata promotes human gingival fibroblast well-being
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7997630/
https://www.ncbi.nlm.nih.gov/pubmed/32031808
http://dx.doi.org/10.1021/acs.jnatprod.9b01030
work_keys_str_mv AT iannuzziannamaria antioxidantactivityofcompoundsisolatedfromelaeagnusumbellatapromoteshumangingivalfibroblastwellbeing
AT giacomellichiara antioxidantactivityofcompoundsisolatedfromelaeagnusumbellatapromoteshumangingivalfibroblastwellbeing
AT deleomarinella antioxidantactivityofcompoundsisolatedfromelaeagnusumbellatapromoteshumangingivalfibroblastwellbeing
AT pietrobonodeborah antioxidantactivityofcompoundsisolatedfromelaeagnusumbellatapromoteshumangingivalfibroblastwellbeing
AT camangifabiano antioxidantactivityofcompoundsisolatedfromelaeagnusumbellatapromoteshumangingivalfibroblastwellbeing
AT detommasinunziatina antioxidantactivityofcompoundsisolatedfromelaeagnusumbellatapromoteshumangingivalfibroblastwellbeing
AT martiniclaudia antioxidantactivityofcompoundsisolatedfromelaeagnusumbellatapromoteshumangingivalfibroblastwellbeing
AT trincavellimarialetizia antioxidantactivityofcompoundsisolatedfromelaeagnusumbellatapromoteshumangingivalfibroblastwellbeing
AT bracaalessandra antioxidantactivityofcompoundsisolatedfromelaeagnusumbellatapromoteshumangingivalfibroblastwellbeing

Ejemplares similares