Genomic epidemiology of COVID-19 in care homes in the east of England

COVID-19 poses a major challenge to care homes, as SARS-CoV-2 is readily transmitted and causes disproportionately severe disease in older people. Here, 1167 residents from 337 care homes were identified from a dataset of 6600 COVID-19 cases from the East of England. Older age and being a care home...

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Detalles Bibliográficos
Autores principales: Hamilton, William L, Tonkin-Hill, Gerry, Smith, Emily R, Aggarwal, Dinesh, Houldcroft, Charlotte J, Warne, Ben, Meredith, Luke W, Hosmillo, Myra, Jahun, Aminu S, Curran, Martin D, Parmar, Surendra, Caller, Laura G, Caddy, Sarah L, Khokhar, Fahad A, Yakovleva, Anna, Hall, Grant, Feltwell, Theresa, Pinckert, Malte L, Georgana, Iliana, Chaudhry, Yasmin, Brown, Colin S, Gonçalves, Sonia, Amato, Roberto, Harrison, Ewan M, Brown, Nicholas M, Beale, Mathew A, Spencer Chapman, Michael, Jackson, David K, Johnston, Ian, Alderton, Alex, Sillitoe, John, Langford, Cordelia, Dougan, Gordon, Peacock, Sharon J, Kwiatowski, Dominic P, Goodfellow, Ian G, Torok, M Estee
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2021
Materias:
Epidemiology and Global Health
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7997667/
https://www.ncbi.nlm.nih.gov/pubmed/33650490
http://dx.doi.org/10.7554/eLife.64618
Descripción
Sumario:COVID-19 poses a major challenge to care homes, as SARS-CoV-2 is readily transmitted and causes disproportionately severe disease in older people. Here, 1167 residents from 337 care homes were identified from a dataset of 6600 COVID-19 cases from the East of England. Older age and being a care home resident were associated with increased mortality. SARS-CoV-2 genomes were available for 700 residents from 292 care homes. By integrating genomic and temporal data, 409 viral clusters within the 292 homes were identified, indicating two different patterns – outbreaks among care home residents and independent introductions with limited onward transmission. Approximately 70% of residents in the genomic analysis were admitted to hospital during the study, providing extensive opportunities for transmission between care homes and hospitals. Limiting viral transmission within care homes should be a key target for infection control to reduce COVID-19 mortality in this population.

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