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Genomic epidemiology of COVID-19 in care homes in the east of England
COVID-19 poses a major challenge to care homes, as SARS-CoV-2 is readily transmitted and causes disproportionately severe disease in older people. Here, 1167 residents from 337 care homes were identified from a dataset of 6600 COVID-19 cases from the East of England. Older age and being a care home...
| Autores principales: | , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
eLife Sciences Publications, Ltd
2021
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7997667/ https://www.ncbi.nlm.nih.gov/pubmed/33650490 http://dx.doi.org/10.7554/eLife.64618 |
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| author | Hamilton, William L Tonkin-Hill, Gerry Smith, Emily R Aggarwal, Dinesh Houldcroft, Charlotte J Warne, Ben Meredith, Luke W Hosmillo, Myra Jahun, Aminu S Curran, Martin D Parmar, Surendra Caller, Laura G Caddy, Sarah L Khokhar, Fahad A Yakovleva, Anna Hall, Grant Feltwell, Theresa Pinckert, Malte L Georgana, Iliana Chaudhry, Yasmin Brown, Colin S Gonçalves, Sonia Amato, Roberto Harrison, Ewan M Brown, Nicholas M Beale, Mathew A Spencer Chapman, Michael Jackson, David K Johnston, Ian Alderton, Alex Sillitoe, John Langford, Cordelia Dougan, Gordon Peacock, Sharon J Kwiatowski, Dominic P Goodfellow, Ian G Torok, M Estee |
| author_facet | Hamilton, William L Tonkin-Hill, Gerry Smith, Emily R Aggarwal, Dinesh Houldcroft, Charlotte J Warne, Ben Meredith, Luke W Hosmillo, Myra Jahun, Aminu S Curran, Martin D Parmar, Surendra Caller, Laura G Caddy, Sarah L Khokhar, Fahad A Yakovleva, Anna Hall, Grant Feltwell, Theresa Pinckert, Malte L Georgana, Iliana Chaudhry, Yasmin Brown, Colin S Gonçalves, Sonia Amato, Roberto Harrison, Ewan M Brown, Nicholas M Beale, Mathew A Spencer Chapman, Michael Jackson, David K Johnston, Ian Alderton, Alex Sillitoe, John Langford, Cordelia Dougan, Gordon Peacock, Sharon J Kwiatowski, Dominic P Goodfellow, Ian G Torok, M Estee |
| author_sort | Hamilton, William L |
| collection | PubMed |
| description | COVID-19 poses a major challenge to care homes, as SARS-CoV-2 is readily transmitted and causes disproportionately severe disease in older people. Here, 1167 residents from 337 care homes were identified from a dataset of 6600 COVID-19 cases from the East of England. Older age and being a care home resident were associated with increased mortality. SARS-CoV-2 genomes were available for 700 residents from 292 care homes. By integrating genomic and temporal data, 409 viral clusters within the 292 homes were identified, indicating two different patterns – outbreaks among care home residents and independent introductions with limited onward transmission. Approximately 70% of residents in the genomic analysis were admitted to hospital during the study, providing extensive opportunities for transmission between care homes and hospitals. Limiting viral transmission within care homes should be a key target for infection control to reduce COVID-19 mortality in this population. |
| format | Online Article Text |
| id | pubmed-7997667 |
| institution | National Center for Biotechnology Information |
| language | English |
| publishDate | 2021 |
| publisher | eLife Sciences Publications, Ltd |
| record_format | MEDLINE/PubMed |
| spelling | pubmed-79976672021-03-31 Genomic epidemiology of COVID-19 in care homes in the east of England Hamilton, William L Tonkin-Hill, Gerry Smith, Emily R Aggarwal, Dinesh Houldcroft, Charlotte J Warne, Ben Meredith, Luke W Hosmillo, Myra Jahun, Aminu S Curran, Martin D Parmar, Surendra Caller, Laura G Caddy, Sarah L Khokhar, Fahad A Yakovleva, Anna Hall, Grant Feltwell, Theresa Pinckert, Malte L Georgana, Iliana Chaudhry, Yasmin Brown, Colin S Gonçalves, Sonia Amato, Roberto Harrison, Ewan M Brown, Nicholas M Beale, Mathew A Spencer Chapman, Michael Jackson, David K Johnston, Ian Alderton, Alex Sillitoe, John Langford, Cordelia Dougan, Gordon Peacock, Sharon J Kwiatowski, Dominic P Goodfellow, Ian G Torok, M Estee eLife Epidemiology and Global Health COVID-19 poses a major challenge to care homes, as SARS-CoV-2 is readily transmitted and causes disproportionately severe disease in older people. Here, 1167 residents from 337 care homes were identified from a dataset of 6600 COVID-19 cases from the East of England. Older age and being a care home resident were associated with increased mortality. SARS-CoV-2 genomes were available for 700 residents from 292 care homes. By integrating genomic and temporal data, 409 viral clusters within the 292 homes were identified, indicating two different patterns – outbreaks among care home residents and independent introductions with limited onward transmission. Approximately 70% of residents in the genomic analysis were admitted to hospital during the study, providing extensive opportunities for transmission between care homes and hospitals. Limiting viral transmission within care homes should be a key target for infection control to reduce COVID-19 mortality in this population. eLife Sciences Publications, Ltd 2021-03-02 /pmc/articles/PMC7997667/ /pubmed/33650490 http://dx.doi.org/10.7554/eLife.64618 Text en © 2021, Hamilton et al https://creativecommons.org/licenses/by/4.0/This article is distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use and redistribution provided that the original author and source are credited. |
| spellingShingle | Epidemiology and Global Health Hamilton, William L Tonkin-Hill, Gerry Smith, Emily R Aggarwal, Dinesh Houldcroft, Charlotte J Warne, Ben Meredith, Luke W Hosmillo, Myra Jahun, Aminu S Curran, Martin D Parmar, Surendra Caller, Laura G Caddy, Sarah L Khokhar, Fahad A Yakovleva, Anna Hall, Grant Feltwell, Theresa Pinckert, Malte L Georgana, Iliana Chaudhry, Yasmin Brown, Colin S Gonçalves, Sonia Amato, Roberto Harrison, Ewan M Brown, Nicholas M Beale, Mathew A Spencer Chapman, Michael Jackson, David K Johnston, Ian Alderton, Alex Sillitoe, John Langford, Cordelia Dougan, Gordon Peacock, Sharon J Kwiatowski, Dominic P Goodfellow, Ian G Torok, M Estee Genomic epidemiology of COVID-19 in care homes in the east of England |
| title | Genomic epidemiology of COVID-19 in care homes in the east of England |
| title_full | Genomic epidemiology of COVID-19 in care homes in the east of England |
| title_fullStr | Genomic epidemiology of COVID-19 in care homes in the east of England |
| title_full_unstemmed | Genomic epidemiology of COVID-19 in care homes in the east of England |
| title_short | Genomic epidemiology of COVID-19 in care homes in the east of England |
| title_sort | genomic epidemiology of covid-19 in care homes in the east of england |
| topic | Epidemiology and Global Health |
| url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7997667/ https://www.ncbi.nlm.nih.gov/pubmed/33650490 http://dx.doi.org/10.7554/eLife.64618 |
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