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Pathophysiology of light phenotype SARS-CoV-2 interstitial pneumonia: from histopathological features to clinical presentations

Little is known about the light phenotype of SARS-CoV-2 pneumonia, which behaves in an unusual way, unlike other known respiratory diseases. We believe that the histopathological features of early COVID-19 could be considered the pathophysiological hallmark of this disease. Lung cryobiopsies show al...

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Detalles Bibliográficos
Autores principales: Oldani, S., Ravaglia, C., Bensai, S., Bertolovic, L., Ghirotti, C., Puglisi, S., Martinello, S., Sultani, F., Colinelli, C., Piciucchi, S., Simoncelli, S., Poletti, V.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Sociedade Portuguesa de Pneumologia. Published by Elsevier España, S.L.U. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7997696/
https://www.ncbi.nlm.nih.gov/pubmed/33832850
http://dx.doi.org/10.1016/j.pulmoe.2021.03.003
Descripción
Sumario:Little is known about the light phenotype of SARS-CoV-2 pneumonia, which behaves in an unusual way, unlike other known respiratory diseases. We believe that the histopathological features of early COVID-19 could be considered the pathophysiological hallmark of this disease. Lung cryobiopsies show almost pristine alveoli, enlarged/hyperplasic alveolar capillaries along with dilatation of the post capillary pulmonary venules. Hypoxemia could therefore be explained by a reduction of the normal V/Q ratio, due to blood overflow around well ventilated alveoli. This could clarify typical manifestations of type L COVID-19, such as happy hypoxemia, response to awake prone positioning, response to PEEP/CPAP and platypnea orthodeoxia.