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Oncolytic virotherapy induced CSDE1 neo-antigenesis restricts VSV replication but can be targeted by immunotherapy
In our clinical trials of oncolytic vesicular stomatitis virus expressing interferon beta (VSV-IFNβ), several patients achieved initial responses followed by aggressive relapse. We show here that VSV-IFNβ-escape tumors predictably express a point-mutated CSDE1(P5S) form of the RNA-binding Cold Shock...
Autores principales: | Kottke, Timothy, Tonne, Jason, Evgin, Laura, Driscoll, Christopher B., van Vloten, Jacob, Jennings, Victoria A., Huff, Amanda L., Zell, Brady, Thompson, Jill M., Wongthida, Phonphimon, Pulido, Jose, Schuelke, Matthew R., Samson, Adel, Selby, Peter, Ilett, Elizabeth, McNiven, Mark, Roberts, Lewis R., Borad, Mitesh J., Pandha, Hardev, Harrington, Kevin, Melcher, Alan, Vile, Richard G. |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7997928/ https://www.ncbi.nlm.nih.gov/pubmed/33772027 http://dx.doi.org/10.1038/s41467-021-22115-1 |
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