Inhibiting LXRα phosphorylation in hematopoietic cells reduces inflammation and attenuates atherosclerosis and obesity in mice

Atherosclerosis and obesity share pathological features including inflammation mediated by innate and adaptive immune cells. LXRα plays a central role in the transcription of inflammatory and metabolic genes. LXRα is modulated by phosphorylation at serine 196 (LXRα pS196), however, the consequences...

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Detalles Bibliográficos
Autores principales: Voisin, Maud, Shrestha, Elina, Rollet, Claire, Nikain, Cyrus A., Josefs, Tatjana, Mahé, Mélanie, Barrett, Tessa J., Chang, Hye Rim, Ruoff, Rachel, Schneider, Jeffrey A., Garabedian, Michela L., Zoumadakis, Chris, Yun, Chi, Badwan, Bara, Brown, Emily J., Mar, Adam C., Schneider, Robert J., Goldberg, Ira J., Pineda-Torra, Inés, Fisher, Edward A., Garabedian, Michael J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7997930/
https://www.ncbi.nlm.nih.gov/pubmed/33772096
http://dx.doi.org/10.1038/s42003-021-01925-5

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