Cytoplasmic DNA accumulation preferentially triggers cell death of myeloid leukemia cells by interacting with intracellular DNA sensing pathway

Accumulating evidence indicates the presence of cytoplasmic DNAs in various types of malignant cells, and its involvement in anti-cancer drug- or radiotherapy-mediated DNA damage response and replication stress. However, the pathophysiological roles of cytoplasmic DNAs in leukemias remain largely un...

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Detalles Bibliográficos
Autores principales: Baba, Tomohisa, Yoshida, Takeshi, Tanabe, Yamato, Nishimura, Tatsunori, Morishita, Soji, Gotoh, Noriko, Hirao, Atsushi, Hanayama, Rikinari, Mukaida, Naofumi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7997981/
https://www.ncbi.nlm.nih.gov/pubmed/33771977
http://dx.doi.org/10.1038/s41419-021-03587-x

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