A proof-of-concept study for the pathogenetic role of enhancer hypomethylation of MYBPHL in multiple myeloma

Enhancer DNA methylation and expression of MYBPHL was studied in multiple myeloma (MM). By bisulfite genomic sequencing, among the three CpGs inside the MYBPHL enhancer, CpG1 was significantly hypomethylated in MM cell lines (6.7–50.0%) than normal plasma cells (37.5–75.0%) (P = 0.007), which was ne...

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Detalles Bibliográficos
Autores principales: Wong, Kwan Yeung, Morgan, Gareth J., Boyle, Eileen M., Cheng, Alfred Sze Lok, Yip, Kevin Yuk-Lap, Chim, Chor Sang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7997988/
https://www.ncbi.nlm.nih.gov/pubmed/33772052
http://dx.doi.org/10.1038/s41598-021-86473-y

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7997988/
https://www.ncbi.nlm.nih.gov/pubmed/33772052
http://dx.doi.org/10.1038/s41598-021-86473-y

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