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TDP-43 and PINK1 mediate CHCHD10(S59L) mutation–induced defects in Drosophila and in vitro

Mutations in coiled-coil-helix-coiled-coil-helix domain containing 10 (CHCHD10) can cause amyotrophic lateral sclerosis and frontotemporal dementia (ALS-FTD). However, the underlying mechanisms are unclear. Here, we generate CHCH10(S59L)-mutant Drosophila melanogaster and HeLa cell lines to model CH...

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Detalles Bibliográficos
Autores principales:	Baek, Minwoo, Choe, Yun-Jeong, Bannwarth, Sylvie, Kim, JiHye, Maitra, Swati, Dorn, Gerald W., Taylor, J. Paul, Paquis-Flucklinger, Veronique, Kim, Nam Chul
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2021
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7997989/ https://www.ncbi.nlm.nih.gov/pubmed/33772006 http://dx.doi.org/10.1038/s41467-021-22145-9

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