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DNA replication origins retain mobile licensing proteins

DNA replication in eukaryotes initiates at many origins distributed across each chromosome. Origins are bound by the origin recognition complex (ORC), which, with Cdc6 and Cdt1, recruits and loads the Mcm2-7 (MCM) helicase as an inactive double hexamer during G1 phase. The replisome assembles at the...

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Detalles Bibliográficos
Autores principales:	Sánchez, Humberto, McCluskey, Kaley, van Laar, Theo, van Veen, Edo, Asscher, Filip M., Solano, Belén, Diffley, John F. X., Dekker, Nynke H.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2021
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7998030/ https://www.ncbi.nlm.nih.gov/pubmed/33772005 http://dx.doi.org/10.1038/s41467-021-22216-x

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