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Validation of diffuse correlation spectroscopy measures of critical closing pressure against transcranial Doppler ultrasound in stroke patients

Significance: Intracranial pressure (ICP), variability in perfusion, and resulting ischemia are leading causes of secondary brain injury in patients treated in the neurointensive care unit. Continuous, accurate monitoring of cerebral blood flow (CBF) and ICP guide intervention and ultimately reduce...

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Autores principales: Wu, Kuan-Cheng, Sunwoo, John, Sheriff, Faheem, Farzam, Parisa, Farzam, Parya Y., Orihuela-Espina, Felipe, LaRose, Sarah L., Monk, Andrew D., Aziz-Sultan, Mohammad A., Patel, Nirav, Vaitkevicius, Henrikas, Franceschini, Maria Angela
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Society of Photo-Optical Instrumentation Engineers 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7998065/
https://www.ncbi.nlm.nih.gov/pubmed/33774980
http://dx.doi.org/10.1117/1.JBO.26.3.036008
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author Wu, Kuan-Cheng
Sunwoo, John
Sheriff, Faheem
Farzam, Parisa
Farzam, Parya Y.
Orihuela-Espina, Felipe
LaRose, Sarah L.
Monk, Andrew D.
Aziz-Sultan, Mohammad A.
Patel, Nirav
Vaitkevicius, Henrikas
Franceschini, Maria Angela
author_facet Wu, Kuan-Cheng
Sunwoo, John
Sheriff, Faheem
Farzam, Parisa
Farzam, Parya Y.
Orihuela-Espina, Felipe
LaRose, Sarah L.
Monk, Andrew D.
Aziz-Sultan, Mohammad A.
Patel, Nirav
Vaitkevicius, Henrikas
Franceschini, Maria Angela
author_sort Wu, Kuan-Cheng
collection PubMed
description Significance: Intracranial pressure (ICP), variability in perfusion, and resulting ischemia are leading causes of secondary brain injury in patients treated in the neurointensive care unit. Continuous, accurate monitoring of cerebral blood flow (CBF) and ICP guide intervention and ultimately reduce morbidity and mortality. Currently, only invasive tools are used to monitor patients at high risk for intracranial hypertension. Aim: Diffuse correlation spectroscopy (DCS), a noninvasive near-infrared optical technique, is emerging as a possible method for continuous monitoring of CBF and critical closing pressure (CrCP or zero-flow pressure), a parameter directly related to ICP. Approach: We optimized DCS hardware and algorithms for the quantification of CrCP. Toward its clinical translation, we validated the DCS estimates of cerebral blood flow index ([Formula: see text]) and CrCP in ischemic stroke patients with respect to simultaneously acquired transcranial Doppler ultrasound (TCD) cerebral blood flow velocity (CBFV) and CrCP. Results: We found CrCP derived from DCS and TCD were highly linearly correlated (ipsilateral [Formula: see text] , [Formula: see text]; contralateral [Formula: see text] , [Formula: see text]). We found weaker correlations between [Formula: see text] and CBFV (ipsilateral [Formula: see text] , [Formula: see text]; contralateral [Formula: see text] , [Formula: see text]) probably due to the different vasculature measured. Conclusion: Our results suggest DCS is a valid alternative to TCD for continuous monitoring of CrCP.
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spelling pubmed-79980652021-03-29 Validation of diffuse correlation spectroscopy measures of critical closing pressure against transcranial Doppler ultrasound in stroke patients Wu, Kuan-Cheng Sunwoo, John Sheriff, Faheem Farzam, Parisa Farzam, Parya Y. Orihuela-Espina, Felipe LaRose, Sarah L. Monk, Andrew D. Aziz-Sultan, Mohammad A. Patel, Nirav Vaitkevicius, Henrikas Franceschini, Maria Angela J Biomed Opt Imaging Significance: Intracranial pressure (ICP), variability in perfusion, and resulting ischemia are leading causes of secondary brain injury in patients treated in the neurointensive care unit. Continuous, accurate monitoring of cerebral blood flow (CBF) and ICP guide intervention and ultimately reduce morbidity and mortality. Currently, only invasive tools are used to monitor patients at high risk for intracranial hypertension. Aim: Diffuse correlation spectroscopy (DCS), a noninvasive near-infrared optical technique, is emerging as a possible method for continuous monitoring of CBF and critical closing pressure (CrCP or zero-flow pressure), a parameter directly related to ICP. Approach: We optimized DCS hardware and algorithms for the quantification of CrCP. Toward its clinical translation, we validated the DCS estimates of cerebral blood flow index ([Formula: see text]) and CrCP in ischemic stroke patients with respect to simultaneously acquired transcranial Doppler ultrasound (TCD) cerebral blood flow velocity (CBFV) and CrCP. Results: We found CrCP derived from DCS and TCD were highly linearly correlated (ipsilateral [Formula: see text] , [Formula: see text]; contralateral [Formula: see text] , [Formula: see text]). We found weaker correlations between [Formula: see text] and CBFV (ipsilateral [Formula: see text] , [Formula: see text]; contralateral [Formula: see text] , [Formula: see text]) probably due to the different vasculature measured. Conclusion: Our results suggest DCS is a valid alternative to TCD for continuous monitoring of CrCP. Society of Photo-Optical Instrumentation Engineers 2021-03-27 2021-03 /pmc/articles/PMC7998065/ /pubmed/33774980 http://dx.doi.org/10.1117/1.JBO.26.3.036008 Text en © 2021 The Authors https://creativecommons.org/licenses/by/4.0/ Published by SPIE under a Creative Commons Attribution 4.0 Unported License. Distribution or reproduction of this work in whole or in part requires full attribution of the original publication, including its DOI.
spellingShingle Imaging
Wu, Kuan-Cheng
Sunwoo, John
Sheriff, Faheem
Farzam, Parisa
Farzam, Parya Y.
Orihuela-Espina, Felipe
LaRose, Sarah L.
Monk, Andrew D.
Aziz-Sultan, Mohammad A.
Patel, Nirav
Vaitkevicius, Henrikas
Franceschini, Maria Angela
Validation of diffuse correlation spectroscopy measures of critical closing pressure against transcranial Doppler ultrasound in stroke patients
title Validation of diffuse correlation spectroscopy measures of critical closing pressure against transcranial Doppler ultrasound in stroke patients
title_full Validation of diffuse correlation spectroscopy measures of critical closing pressure against transcranial Doppler ultrasound in stroke patients
title_fullStr Validation of diffuse correlation spectroscopy measures of critical closing pressure against transcranial Doppler ultrasound in stroke patients
title_full_unstemmed Validation of diffuse correlation spectroscopy measures of critical closing pressure against transcranial Doppler ultrasound in stroke patients
title_short Validation of diffuse correlation spectroscopy measures of critical closing pressure against transcranial Doppler ultrasound in stroke patients
title_sort validation of diffuse correlation spectroscopy measures of critical closing pressure against transcranial doppler ultrasound in stroke patients
topic Imaging
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7998065/
https://www.ncbi.nlm.nih.gov/pubmed/33774980
http://dx.doi.org/10.1117/1.JBO.26.3.036008
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