Cargando…
Validation of joint space narrowing on plain radiographs and its relevance to partial knee arthroplasty: radiological and MRI data from the Osteoarthritis Initiative
AIMS: To explore the clinical relevance of joint space width (JSW) narrowing on standardized-flexion (SF) radiographs in the assessment of cartilage degeneration in specific subregions seen on MRI sequences in knee osteoarthritis (OA) with neutral, valgus, and varus alignments, and potential plannin...
Autores principales: | , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
The British Editorial Society of Bone & Joint Surgery
2021
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7998068/ https://www.ncbi.nlm.nih.gov/pubmed/33685206 http://dx.doi.org/10.1302/2046-3758.103.BJR-2020-0216.R1 |
_version_ | 1783670466390523904 |
---|---|
author | Khury, Farouk Fuchs, Michael Awan Malik, Hassan Leiprecht, Janina Reichel, Heiko Faschingbauer, Martin |
author_facet | Khury, Farouk Fuchs, Michael Awan Malik, Hassan Leiprecht, Janina Reichel, Heiko Faschingbauer, Martin |
author_sort | Khury, Farouk |
collection | PubMed |
description | AIMS: To explore the clinical relevance of joint space width (JSW) narrowing on standardized-flexion (SF) radiographs in the assessment of cartilage degeneration in specific subregions seen on MRI sequences in knee osteoarthritis (OA) with neutral, valgus, and varus alignments, and potential planning of partial knee arthroplasty. METHODS: We retrospectively reviewed 639 subjects, aged 45 to 79 years, in the Osteoarthritis Initiative (OAI) study, who had symptomatic knees with Kellgren and Lawrence grade 2 to 4. Knees were categorized as neutral, valgus, and varus knees by measuring hip-knee-angles on hip-knee-ankle radiographs. Femorotibial JSW was measured on posteroanterior SF radiographs using a special software. The femorotibial compartment was divided into 16 subregions, and MR-tomographic measurements of cartilage volume, thickness, and subchondral bone area were documented. Linear regression with adjustment for age, sex, body mass index, and Kellgren and Lawrence grade was used. RESULTS: We studied 345 neutral, 87 valgus, and 207 varus knees. Radiological JSW narrowing was significantly (p < 0.01) associated with cartilage volume and thickness in medial femorotibial compartment in neutral (r = 0.78, odds ratio (OR) 2.33) and varus knees (r = 0.86, OR 1.92), and in lateral tibial subregions in valgus knees (r = 0.87, OR 3.71). A significant negative correlation was found between JSW narrowing and area of subchondral bone in external lateral tibial subregion in valgus knees (r = −0.65, p < 0.01) and in external medial tibial subregion in varus knees (r = −0.77, p < 0.01). No statistically significant correlation was found in anterior and posterior subregions. CONCLUSION: SF radiographs can be potentially used for initial detection of cartilage degeneration as assessed by MRI in medial and lateral but not in anterior or posterior subregions. Cite this article: Bone Joint Res 2021;10(3):173–187. |
format | Online Article Text |
id | pubmed-7998068 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | The British Editorial Society of Bone & Joint Surgery |
record_format | MEDLINE/PubMed |
spelling | pubmed-79980682021-04-01 Validation of joint space narrowing on plain radiographs and its relevance to partial knee arthroplasty: radiological and MRI data from the Osteoarthritis Initiative Khury, Farouk Fuchs, Michael Awan Malik, Hassan Leiprecht, Janina Reichel, Heiko Faschingbauer, Martin Bone Joint Res Cartilage AIMS: To explore the clinical relevance of joint space width (JSW) narrowing on standardized-flexion (SF) radiographs in the assessment of cartilage degeneration in specific subregions seen on MRI sequences in knee osteoarthritis (OA) with neutral, valgus, and varus alignments, and potential planning of partial knee arthroplasty. METHODS: We retrospectively reviewed 639 subjects, aged 45 to 79 years, in the Osteoarthritis Initiative (OAI) study, who had symptomatic knees with Kellgren and Lawrence grade 2 to 4. Knees were categorized as neutral, valgus, and varus knees by measuring hip-knee-angles on hip-knee-ankle radiographs. Femorotibial JSW was measured on posteroanterior SF radiographs using a special software. The femorotibial compartment was divided into 16 subregions, and MR-tomographic measurements of cartilage volume, thickness, and subchondral bone area were documented. Linear regression with adjustment for age, sex, body mass index, and Kellgren and Lawrence grade was used. RESULTS: We studied 345 neutral, 87 valgus, and 207 varus knees. Radiological JSW narrowing was significantly (p < 0.01) associated with cartilage volume and thickness in medial femorotibial compartment in neutral (r = 0.78, odds ratio (OR) 2.33) and varus knees (r = 0.86, OR 1.92), and in lateral tibial subregions in valgus knees (r = 0.87, OR 3.71). A significant negative correlation was found between JSW narrowing and area of subchondral bone in external lateral tibial subregion in valgus knees (r = −0.65, p < 0.01) and in external medial tibial subregion in varus knees (r = −0.77, p < 0.01). No statistically significant correlation was found in anterior and posterior subregions. CONCLUSION: SF radiographs can be potentially used for initial detection of cartilage degeneration as assessed by MRI in medial and lateral but not in anterior or posterior subregions. Cite this article: Bone Joint Res 2021;10(3):173–187. The British Editorial Society of Bone & Joint Surgery 2021-03-09 /pmc/articles/PMC7998068/ /pubmed/33685206 http://dx.doi.org/10.1302/2046-3758.103.BJR-2020-0216.R1 Text en © 2021 Author(s) et al. https://creativecommons.org/licenses/by-nc-nd/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution Non-Commercial No Derivatives (CC BY-NC-ND 4.0) licence, which permits the copying and redistribution of the work only, and provided the original author and source are credited. See https://creativecommons.org/licenses/by-nc-nd/4.0/. |
spellingShingle | Cartilage Khury, Farouk Fuchs, Michael Awan Malik, Hassan Leiprecht, Janina Reichel, Heiko Faschingbauer, Martin Validation of joint space narrowing on plain radiographs and its relevance to partial knee arthroplasty: radiological and MRI data from the Osteoarthritis Initiative |
title | Validation of joint space narrowing on plain radiographs and its relevance to partial knee arthroplasty: radiological and MRI data from the Osteoarthritis Initiative |
title_full | Validation of joint space narrowing on plain radiographs and its relevance to partial knee arthroplasty: radiological and MRI data from the Osteoarthritis Initiative |
title_fullStr | Validation of joint space narrowing on plain radiographs and its relevance to partial knee arthroplasty: radiological and MRI data from the Osteoarthritis Initiative |
title_full_unstemmed | Validation of joint space narrowing on plain radiographs and its relevance to partial knee arthroplasty: radiological and MRI data from the Osteoarthritis Initiative |
title_short | Validation of joint space narrowing on plain radiographs and its relevance to partial knee arthroplasty: radiological and MRI data from the Osteoarthritis Initiative |
title_sort | validation of joint space narrowing on plain radiographs and its relevance to partial knee arthroplasty: radiological and mri data from the osteoarthritis initiative |
topic | Cartilage |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7998068/ https://www.ncbi.nlm.nih.gov/pubmed/33685206 http://dx.doi.org/10.1302/2046-3758.103.BJR-2020-0216.R1 |
work_keys_str_mv | AT khuryfarouk validationofjointspacenarrowingonplainradiographsanditsrelevancetopartialkneearthroplastyradiologicalandmridatafromtheosteoarthritisinitiative AT fuchsmichael validationofjointspacenarrowingonplainradiographsanditsrelevancetopartialkneearthroplastyradiologicalandmridatafromtheosteoarthritisinitiative AT awanmalikhassan validationofjointspacenarrowingonplainradiographsanditsrelevancetopartialkneearthroplastyradiologicalandmridatafromtheosteoarthritisinitiative AT leiprechtjanina validationofjointspacenarrowingonplainradiographsanditsrelevancetopartialkneearthroplastyradiologicalandmridatafromtheosteoarthritisinitiative AT reichelheiko validationofjointspacenarrowingonplainradiographsanditsrelevancetopartialkneearthroplastyradiologicalandmridatafromtheosteoarthritisinitiative AT faschingbauermartin validationofjointspacenarrowingonplainradiographsanditsrelevancetopartialkneearthroplastyradiologicalandmridatafromtheosteoarthritisinitiative |