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Synthesis of Two Methotrexate Prodrugs for Optimizing Drug Loading into Liposomes
Methotrexate (MTX), a compound originally used as an anticancer drug, has also found applications in a broad variety of autoimmune disorders thanks to its anti-inflammation and immunomodulatory functions. The broad application of MTX is anyway limited by its poor solubility in biological fluids, its...
| Autores principales: | , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
MDPI
2021
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7998143/ https://www.ncbi.nlm.nih.gov/pubmed/33806703 http://dx.doi.org/10.3390/pharmaceutics13030332 |