8-Hydroxybriaranes from Octocoral Briareum stechei (Briareidae) (Kükenthal, 1908)

Chemical investigation of the octocoral Briareum stechei, collected in the Ie Island, Okinawa, Japan, resulted in the isolation of a new briarane-type diterpenoid, briastecholide A (1), as well as the previously reported metabolites, solenolide C (2) and briarenolide S (3). The structures of briaran...

Descripción completa

Detalles Bibliográficos
Autores principales: Huynh, Thanh-Hao, Chien, Su-Ying, Tanaka, Junichi, Wen, Zhi-Hong, Wu, Yang-Chang, Wu, Tung-Ying, Sung, Ping-Jyun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7998228/
https://www.ncbi.nlm.nih.gov/pubmed/33671058
http://dx.doi.org/10.3390/md19030136
_version_ 1783670503581417472
author Huynh, Thanh-Hao
Chien, Su-Ying
Tanaka, Junichi
Wen, Zhi-Hong
Wu, Yang-Chang
Wu, Tung-Ying
Sung, Ping-Jyun
author_facet Huynh, Thanh-Hao
Chien, Su-Ying
Tanaka, Junichi
Wen, Zhi-Hong
Wu, Yang-Chang
Wu, Tung-Ying
Sung, Ping-Jyun
author_sort Huynh, Thanh-Hao
collection PubMed
description Chemical investigation of the octocoral Briareum stechei, collected in the Ie Island, Okinawa, Japan, resulted in the isolation of a new briarane-type diterpenoid, briastecholide A (1), as well as the previously reported metabolites, solenolide C (2) and briarenolide S (3). The structures of briaranes 1–3 were characterized through spectroscopic analysis, and the absolute configuration of 2 was corroborated by a single-crystal X-ray diffraction analysis. Briarane 3 exhibited bioactivity against the protein expression of inducible nitric oxide synthase (iNOS).
format Online
Article
Text
id pubmed-7998228
institution National Center for Biotechnology Information
language English
publishDate 2021
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-79982282021-03-28 8-Hydroxybriaranes from Octocoral Briareum stechei (Briareidae) (Kükenthal, 1908) Huynh, Thanh-Hao Chien, Su-Ying Tanaka, Junichi Wen, Zhi-Hong Wu, Yang-Chang Wu, Tung-Ying Sung, Ping-Jyun Mar Drugs Article Chemical investigation of the octocoral Briareum stechei, collected in the Ie Island, Okinawa, Japan, resulted in the isolation of a new briarane-type diterpenoid, briastecholide A (1), as well as the previously reported metabolites, solenolide C (2) and briarenolide S (3). The structures of briaranes 1–3 were characterized through spectroscopic analysis, and the absolute configuration of 2 was corroborated by a single-crystal X-ray diffraction analysis. Briarane 3 exhibited bioactivity against the protein expression of inducible nitric oxide synthase (iNOS). MDPI 2021-02-28 /pmc/articles/PMC7998228/ /pubmed/33671058 http://dx.doi.org/10.3390/md19030136 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) ).
spellingShingle Article
Huynh, Thanh-Hao
Chien, Su-Ying
Tanaka, Junichi
Wen, Zhi-Hong
Wu, Yang-Chang
Wu, Tung-Ying
Sung, Ping-Jyun
8-Hydroxybriaranes from Octocoral Briareum stechei (Briareidae) (Kükenthal, 1908)
title 8-Hydroxybriaranes from Octocoral Briareum stechei (Briareidae) (Kükenthal, 1908)
title_full 8-Hydroxybriaranes from Octocoral Briareum stechei (Briareidae) (Kükenthal, 1908)
title_fullStr 8-Hydroxybriaranes from Octocoral Briareum stechei (Briareidae) (Kükenthal, 1908)
title_full_unstemmed 8-Hydroxybriaranes from Octocoral Briareum stechei (Briareidae) (Kükenthal, 1908)
title_short 8-Hydroxybriaranes from Octocoral Briareum stechei (Briareidae) (Kükenthal, 1908)
title_sort 8-hydroxybriaranes from octocoral briareum stechei (briareidae) (kükenthal, 1908)
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7998228/
https://www.ncbi.nlm.nih.gov/pubmed/33671058
http://dx.doi.org/10.3390/md19030136
work_keys_str_mv AT huynhthanhhao 8hydroxybriaranesfromoctocoralbriareumstecheibriareidaekukenthal1908
AT chiensuying 8hydroxybriaranesfromoctocoralbriareumstecheibriareidaekukenthal1908
AT tanakajunichi 8hydroxybriaranesfromoctocoralbriareumstecheibriareidaekukenthal1908
AT wenzhihong 8hydroxybriaranesfromoctocoralbriareumstecheibriareidaekukenthal1908
AT wuyangchang 8hydroxybriaranesfromoctocoralbriareumstecheibriareidaekukenthal1908
AT wutungying 8hydroxybriaranesfromoctocoralbriareumstecheibriareidaekukenthal1908
AT sungpingjyun 8hydroxybriaranesfromoctocoralbriareumstecheibriareidaekukenthal1908

Ejemplares similares