Infection of Chinese Rhesus Monkeys with a Subtype C SHIV Resulted in Attenuated In Vivo Viral Replication Despite Successful Animal-to-Animal Serial Passages

Rhesus macaques can be readily infected with chimeric simian-human immunodeficiency viruses (SHIV) as a suitable virus challenge system for testing the efficacy of HIV vaccines. Three Chinese-origin rhesus macaques (ChRM) were inoculated intravenously (IV) with SHIVC109P4 in a rapid serial in vivo p...

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Detalles Bibliográficos
Autores principales: Chege, Gerald K., Adams, Craig H., Keyser, Alana T., Bekker, Valerie, Morris, Lynn, Villinger, Francois J., Williamson, Anna-Lise, Chapman, Rosamund E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7998229/
https://www.ncbi.nlm.nih.gov/pubmed/33801437
http://dx.doi.org/10.3390/v13030397

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