The Cellular Senescence Stress Response in Post-Mitotic Brain Cells: Cell Survival at the Expense of Tissue Degeneration

In 1960, Rita Levi-Montalcini and Barbara Booker made an observation that transformed neuroscience: as neurons mature, they become apoptosis resistant. The following year Leonard Hayflick and Paul Moorhead described a stable replicative arrest of cells in vitro, termed “senescence”. For nearly 60 ye...

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Detalles Bibliográficos
Autores principales: Sah, Eric, Krishnamurthy, Sudarshan, Ahmidouch, Mohamed Y., Gillispie, Gregory J., Milligan, Carol, Orr, Miranda E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7998276/
https://www.ncbi.nlm.nih.gov/pubmed/33799628
http://dx.doi.org/10.3390/life11030229

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