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Semi-Synthesis of Small Molecules of Aminocarbazoles: Tumor Growth Inhibition and Potential Impact on p53

The tumor suppressor p53 is inactivated by mutation in approximately 50% of human cancers. Small molecules that bind and stabilize those mutants may represent effective anticancer drugs. Herein, we report the tumor cell growth inhibitory activity of carbazole alkaloids and amino derivatives, as well...

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Detalles Bibliográficos
Autores principales:	Long, Solida, Loureiro, Joana B., Carvalho, Carla, Gales, Luís, Saraiva, Lucília, Pinto, Madalena M. M., Puthongking, Ploenthip, Sousa, Emília
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2021
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7998292/ https://www.ncbi.nlm.nih.gov/pubmed/33804175 http://dx.doi.org/10.3390/molecules26061637

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