Tioconazole and Chloroquine Act Synergistically to Combat Doxorubicin-Induced Toxicity via Inactivation of PI3K/AKT/mTOR Signaling Mediated ROS-Dependent Apoptosis and Autophagic Flux Inhibition in MCF-7 Breast Cancer Cells

Cancer is a complex devastating disease with enormous treatment challenges, including chemo- and radiotherapeutic resistance. Combination therapy demonstrated a promising strategy to target hard-to-treat cancers and sensitize cancer cells to conventional anti-cancer drugs such as doxorubicin. This s...

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Detalles Bibliográficos
Autores principales: El-Gowily, Afnan H., Loutfy, Samah A., Ali, Ehab M. M., Mohamed, Tarek M., Mansour, Mohammed A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7998405/
https://www.ncbi.nlm.nih.gov/pubmed/33799790
http://dx.doi.org/10.3390/ph14030254

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