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Anticancer Mechanism of Curcumin on Human Glioblastoma
Glioblastoma (GBM) is the most malignant brain tumor and accounts for most adult brain tumors. Current available treatment options for GBM are multimodal, which include surgical resection, radiation, and chemotherapy. Despite the significant advances in diagnostic and therapeutic approaches, GBM rem...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7998496/ https://www.ncbi.nlm.nih.gov/pubmed/33809462 http://dx.doi.org/10.3390/nu13030950 |
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author | Wong, Shu Chyi Kamarudin, Muhamad Noor Alfarizal Naidu, Rakesh |
author_facet | Wong, Shu Chyi Kamarudin, Muhamad Noor Alfarizal Naidu, Rakesh |
author_sort | Wong, Shu Chyi |
collection | PubMed |
description | Glioblastoma (GBM) is the most malignant brain tumor and accounts for most adult brain tumors. Current available treatment options for GBM are multimodal, which include surgical resection, radiation, and chemotherapy. Despite the significant advances in diagnostic and therapeutic approaches, GBM remains largely resistant to treatment, with a poor median survival rate between 12 and 18 months. With increasing drug resistance, the introduction of phytochemicals into current GBM treatment has become a potential strategy to combat GBM. Phytochemicals possess multifarious bioactivities with multitarget sites and comparatively marginal toxicity. Among them, curcumin is the most studied compound described as a potential anticancer agent due to its multi-targeted signaling/molecular pathways properties. Curcumin possesses the ability to modulate the core pathways involved in GBM cell proliferation, apoptosis, cell cycle arrest, autophagy, paraptosis, oxidative stress, and tumor cell motility. This review discusses curcumin’s anticancer mechanism through modulation of Rb, p53, MAPK, P13K/Akt, JAK/STAT, Shh, and NF-κB pathways, which are commonly involved and dysregulated in preclinical and clinical GBM models. In addition, limitation issues such as bioavailability, pharmacokinetics perspectives strategies, and clinical trials were discussed. |
format | Online Article Text |
id | pubmed-7998496 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-79984962021-03-28 Anticancer Mechanism of Curcumin on Human Glioblastoma Wong, Shu Chyi Kamarudin, Muhamad Noor Alfarizal Naidu, Rakesh Nutrients Review Glioblastoma (GBM) is the most malignant brain tumor and accounts for most adult brain tumors. Current available treatment options for GBM are multimodal, which include surgical resection, radiation, and chemotherapy. Despite the significant advances in diagnostic and therapeutic approaches, GBM remains largely resistant to treatment, with a poor median survival rate between 12 and 18 months. With increasing drug resistance, the introduction of phytochemicals into current GBM treatment has become a potential strategy to combat GBM. Phytochemicals possess multifarious bioactivities with multitarget sites and comparatively marginal toxicity. Among them, curcumin is the most studied compound described as a potential anticancer agent due to its multi-targeted signaling/molecular pathways properties. Curcumin possesses the ability to modulate the core pathways involved in GBM cell proliferation, apoptosis, cell cycle arrest, autophagy, paraptosis, oxidative stress, and tumor cell motility. This review discusses curcumin’s anticancer mechanism through modulation of Rb, p53, MAPK, P13K/Akt, JAK/STAT, Shh, and NF-κB pathways, which are commonly involved and dysregulated in preclinical and clinical GBM models. In addition, limitation issues such as bioavailability, pharmacokinetics perspectives strategies, and clinical trials were discussed. MDPI 2021-03-16 /pmc/articles/PMC7998496/ /pubmed/33809462 http://dx.doi.org/10.3390/nu13030950 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) ). |
spellingShingle | Review Wong, Shu Chyi Kamarudin, Muhamad Noor Alfarizal Naidu, Rakesh Anticancer Mechanism of Curcumin on Human Glioblastoma |
title | Anticancer Mechanism of Curcumin on Human Glioblastoma |
title_full | Anticancer Mechanism of Curcumin on Human Glioblastoma |
title_fullStr | Anticancer Mechanism of Curcumin on Human Glioblastoma |
title_full_unstemmed | Anticancer Mechanism of Curcumin on Human Glioblastoma |
title_short | Anticancer Mechanism of Curcumin on Human Glioblastoma |
title_sort | anticancer mechanism of curcumin on human glioblastoma |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7998496/ https://www.ncbi.nlm.nih.gov/pubmed/33809462 http://dx.doi.org/10.3390/nu13030950 |
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