Regulation of MHC I Molecules in Glioblastoma Cells and the Sensitizing of NK Cells

Immunotherapy has been established as an important area in the therapy of malignant diseases. Immunogenicity sufficient for immune recognition and subsequent elimination can be bypassed by tumors through altered and/or reduced expression levels of major histocompatibility complex class I (MHC I) mol...

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Autores principales: Burster, Timo, Gärtner, Fabian, Bulach, Christiane, Zhanapiya, Anuar, Gihring, Adrian, Knippschild, Uwe
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7998501/
https://www.ncbi.nlm.nih.gov/pubmed/33800301
http://dx.doi.org/10.3390/ph14030236
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author Burster, Timo
Gärtner, Fabian
Bulach, Christiane
Zhanapiya, Anuar
Gihring, Adrian
Knippschild, Uwe
author_facet Burster, Timo
Gärtner, Fabian
Bulach, Christiane
Zhanapiya, Anuar
Gihring, Adrian
Knippschild, Uwe
author_sort Burster, Timo
collection PubMed
description Immunotherapy has been established as an important area in the therapy of malignant diseases. Immunogenicity sufficient for immune recognition and subsequent elimination can be bypassed by tumors through altered and/or reduced expression levels of major histocompatibility complex class I (MHC I) molecules. Natural killer (NK) cells can eliminate tumor cells in a MHC I antigen presentation-independent manner by an array of activating and inhibitory receptors, which are promising candidates for immunotherapy. Here we summarize the latest findings in recognizing and regulating MHC I molecules that affect NK cell surveillance of glioblastoma cells.
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spelling pubmed-79985012021-03-28 Regulation of MHC I Molecules in Glioblastoma Cells and the Sensitizing of NK Cells Burster, Timo Gärtner, Fabian Bulach, Christiane Zhanapiya, Anuar Gihring, Adrian Knippschild, Uwe Pharmaceuticals (Basel) Review Immunotherapy has been established as an important area in the therapy of malignant diseases. Immunogenicity sufficient for immune recognition and subsequent elimination can be bypassed by tumors through altered and/or reduced expression levels of major histocompatibility complex class I (MHC I) molecules. Natural killer (NK) cells can eliminate tumor cells in a MHC I antigen presentation-independent manner by an array of activating and inhibitory receptors, which are promising candidates for immunotherapy. Here we summarize the latest findings in recognizing and regulating MHC I molecules that affect NK cell surveillance of glioblastoma cells. MDPI 2021-03-08 /pmc/articles/PMC7998501/ /pubmed/33800301 http://dx.doi.org/10.3390/ph14030236 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) ).
spellingShingle Review
Burster, Timo
Gärtner, Fabian
Bulach, Christiane
Zhanapiya, Anuar
Gihring, Adrian
Knippschild, Uwe
Regulation of MHC I Molecules in Glioblastoma Cells and the Sensitizing of NK Cells
title Regulation of MHC I Molecules in Glioblastoma Cells and the Sensitizing of NK Cells
title_full Regulation of MHC I Molecules in Glioblastoma Cells and the Sensitizing of NK Cells
title_fullStr Regulation of MHC I Molecules in Glioblastoma Cells and the Sensitizing of NK Cells
title_full_unstemmed Regulation of MHC I Molecules in Glioblastoma Cells and the Sensitizing of NK Cells
title_short Regulation of MHC I Molecules in Glioblastoma Cells and the Sensitizing of NK Cells
title_sort regulation of mhc i molecules in glioblastoma cells and the sensitizing of nk cells
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7998501/
https://www.ncbi.nlm.nih.gov/pubmed/33800301
http://dx.doi.org/10.3390/ph14030236
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