The Effect of NUDT15, TPMT, APEX1, and ITPA Genetic Variations on Mercaptopurine Treatment of Pediatric Acute Lymphoblastic Leukemia

Mercaptopurine (MP) is a commonly used maintenance regimen for childhood acute lymphoblastic leukemia (ALL). However, 6-MP has a narrow therapeutic index, which causes dose-limiting toxicities in hematopoietic tissues. Recent studies reported several candidate pharmacogenetic markers such as TPMT, N...

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Detalles Bibliográficos
Autores principales: Lee, Jae Min, Shim, Ye Jee, Kim, Do-Hoon, Jung, Nani, Ha, Jung-Sook
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7998516/
https://www.ncbi.nlm.nih.gov/pubmed/33804051
http://dx.doi.org/10.3390/children8030224

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7998516/
https://www.ncbi.nlm.nih.gov/pubmed/33804051
http://dx.doi.org/10.3390/children8030224

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