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Facial Rejuvenation with Concentrated Lipograft—A 12 Month Follow-Up Study

Lipofilling is a popular technique to treat volume loss in aging patients. The isolated adipose tissue is composed of adipocytes and stromal vascular fraction cells, which include adipose-derived stem cells (ASC). We hypothesize that the patient’s wrinkle severity scale (WSS) and patient’s satisfact...

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Autores principales: Prantl, Lukas, Brix, Eva, Kempa, Sally, Felthaus, Oliver, Eigenberger, Andreas, Brébant, Vanessa, Anker, Alexandra, Strauss, Catharina
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7998566/
https://www.ncbi.nlm.nih.gov/pubmed/33800325
http://dx.doi.org/10.3390/cells10030594
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author Prantl, Lukas
Brix, Eva
Kempa, Sally
Felthaus, Oliver
Eigenberger, Andreas
Brébant, Vanessa
Anker, Alexandra
Strauss, Catharina
author_facet Prantl, Lukas
Brix, Eva
Kempa, Sally
Felthaus, Oliver
Eigenberger, Andreas
Brébant, Vanessa
Anker, Alexandra
Strauss, Catharina
author_sort Prantl, Lukas
collection PubMed
description Lipofilling is a popular technique to treat volume loss in aging patients. The isolated adipose tissue is composed of adipocytes and stromal vascular fraction cells, which include adipose-derived stem cells (ASC). We hypothesize that the patient’s wrinkle severity scale (WSS) and patient’s satisfaction on the global aesthetic improvement scale (GAIS) can be improved after using concentrated lipoaspirate. Fourteen patients (54 years ± 11.09 years) with volume loss in the midface area underwent waterjet-assisted liposuction (Human Med AG, Schwerin, Germany). Fat was centrifuged in an ACP Double Syringe (Arthrex GmbH, Munich, Germany) using Rotofix 32A centrifuge (Andreas Hettich, GmbH & Co.KG, Tuttlingen, Germany). Homogenization was performed using the double syringe and a 1.4 mm female–female luerlock connector. After a second centrifugation, patients received periorbital (PO) and nasolabial (NL) lipografting. ASC count was performed after enzymatical digestion. Vitality of cells was assessed using a resazurin assay. During long-term follow up (12 months, n = 10), we found a high patient’s satisfaction (GAIS 1+/−0.52) and a good improvement of the WSS during short- and long-term follow-up. The ASC count of processed lipoaspirate was 2.1-fold higher than of unprocessed lipoaspirate (p < 0.001). The difference of ASC in sedimented and simply centrifuged lipoaspirate was also significant (p < 0.05). Facial rejuvenation with concentrated fat graft offers good results concerning objective aesthetic outcome and patient’s satisfaction.
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spelling pubmed-79985662021-03-28 Facial Rejuvenation with Concentrated Lipograft—A 12 Month Follow-Up Study Prantl, Lukas Brix, Eva Kempa, Sally Felthaus, Oliver Eigenberger, Andreas Brébant, Vanessa Anker, Alexandra Strauss, Catharina Cells Article Lipofilling is a popular technique to treat volume loss in aging patients. The isolated adipose tissue is composed of adipocytes and stromal vascular fraction cells, which include adipose-derived stem cells (ASC). We hypothesize that the patient’s wrinkle severity scale (WSS) and patient’s satisfaction on the global aesthetic improvement scale (GAIS) can be improved after using concentrated lipoaspirate. Fourteen patients (54 years ± 11.09 years) with volume loss in the midface area underwent waterjet-assisted liposuction (Human Med AG, Schwerin, Germany). Fat was centrifuged in an ACP Double Syringe (Arthrex GmbH, Munich, Germany) using Rotofix 32A centrifuge (Andreas Hettich, GmbH & Co.KG, Tuttlingen, Germany). Homogenization was performed using the double syringe and a 1.4 mm female–female luerlock connector. After a second centrifugation, patients received periorbital (PO) and nasolabial (NL) lipografting. ASC count was performed after enzymatical digestion. Vitality of cells was assessed using a resazurin assay. During long-term follow up (12 months, n = 10), we found a high patient’s satisfaction (GAIS 1+/−0.52) and a good improvement of the WSS during short- and long-term follow-up. The ASC count of processed lipoaspirate was 2.1-fold higher than of unprocessed lipoaspirate (p < 0.001). The difference of ASC in sedimented and simply centrifuged lipoaspirate was also significant (p < 0.05). Facial rejuvenation with concentrated fat graft offers good results concerning objective aesthetic outcome and patient’s satisfaction. MDPI 2021-03-08 /pmc/articles/PMC7998566/ /pubmed/33800325 http://dx.doi.org/10.3390/cells10030594 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) ).
spellingShingle Article
Prantl, Lukas
Brix, Eva
Kempa, Sally
Felthaus, Oliver
Eigenberger, Andreas
Brébant, Vanessa
Anker, Alexandra
Strauss, Catharina
Facial Rejuvenation with Concentrated Lipograft—A 12 Month Follow-Up Study
title Facial Rejuvenation with Concentrated Lipograft—A 12 Month Follow-Up Study
title_full Facial Rejuvenation with Concentrated Lipograft—A 12 Month Follow-Up Study
title_fullStr Facial Rejuvenation with Concentrated Lipograft—A 12 Month Follow-Up Study
title_full_unstemmed Facial Rejuvenation with Concentrated Lipograft—A 12 Month Follow-Up Study
title_short Facial Rejuvenation with Concentrated Lipograft—A 12 Month Follow-Up Study
title_sort facial rejuvenation with concentrated lipograft—a 12 month follow-up study
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7998566/
https://www.ncbi.nlm.nih.gov/pubmed/33800325
http://dx.doi.org/10.3390/cells10030594
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