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Regulation of Osteoblast Differentiation by Cytokine Networks
Osteoblasts, which are bone-forming cells, play pivotal roles in bone modeling and remodeling. Osteoblast differentiation, also known as osteoblastogenesis, is orchestrated by transcription factors, such as runt-related transcription factor 1/2, osterix, activating transcription factor 4, special AT...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7998677/ https://www.ncbi.nlm.nih.gov/pubmed/33799644 http://dx.doi.org/10.3390/ijms22062851 |
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author | Amarasekara, Dulshara Sachini Kim, Sumi Rho, Jaerang |
author_facet | Amarasekara, Dulshara Sachini Kim, Sumi Rho, Jaerang |
author_sort | Amarasekara, Dulshara Sachini |
collection | PubMed |
description | Osteoblasts, which are bone-forming cells, play pivotal roles in bone modeling and remodeling. Osteoblast differentiation, also known as osteoblastogenesis, is orchestrated by transcription factors, such as runt-related transcription factor 1/2, osterix, activating transcription factor 4, special AT-rich sequence-binding protein 2 and activator protein-1. Osteoblastogenesis is regulated by a network of cytokines under physiological and pathophysiological conditions. Osteoblastogenic cytokines, such as interleukin-10 (IL-10), IL-11, IL-18, interferon-γ (IFN-γ), cardiotrophin-1 and oncostatin M, promote osteoblastogenesis, whereas anti-osteoblastogenic cytokines, such as tumor necrosis factor-α (TNF-α), TNF-β, IL-1α, IL-4, IL-7, IL-12, IL-13, IL-23, IFN-α, IFN-β, leukemia inhibitory factor, cardiotrophin-like cytokine, and ciliary neurotrophic factor, downregulate osteoblastogenesis. Although there are gaps in the body of knowledge regarding the interplay of cytokine networks in osteoblastogenesis, cytokines appear to be potential therapeutic targets in bone-related diseases. Thus, in this study, we review and discuss our osteoblast, osteoblast differentiation, osteoblastogenesis, cytokines, signaling pathway of cytokine networks in osteoblastogenesis. |
format | Online Article Text |
id | pubmed-7998677 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-79986772021-03-28 Regulation of Osteoblast Differentiation by Cytokine Networks Amarasekara, Dulshara Sachini Kim, Sumi Rho, Jaerang Int J Mol Sci Review Osteoblasts, which are bone-forming cells, play pivotal roles in bone modeling and remodeling. Osteoblast differentiation, also known as osteoblastogenesis, is orchestrated by transcription factors, such as runt-related transcription factor 1/2, osterix, activating transcription factor 4, special AT-rich sequence-binding protein 2 and activator protein-1. Osteoblastogenesis is regulated by a network of cytokines under physiological and pathophysiological conditions. Osteoblastogenic cytokines, such as interleukin-10 (IL-10), IL-11, IL-18, interferon-γ (IFN-γ), cardiotrophin-1 and oncostatin M, promote osteoblastogenesis, whereas anti-osteoblastogenic cytokines, such as tumor necrosis factor-α (TNF-α), TNF-β, IL-1α, IL-4, IL-7, IL-12, IL-13, IL-23, IFN-α, IFN-β, leukemia inhibitory factor, cardiotrophin-like cytokine, and ciliary neurotrophic factor, downregulate osteoblastogenesis. Although there are gaps in the body of knowledge regarding the interplay of cytokine networks in osteoblastogenesis, cytokines appear to be potential therapeutic targets in bone-related diseases. Thus, in this study, we review and discuss our osteoblast, osteoblast differentiation, osteoblastogenesis, cytokines, signaling pathway of cytokine networks in osteoblastogenesis. MDPI 2021-03-11 /pmc/articles/PMC7998677/ /pubmed/33799644 http://dx.doi.org/10.3390/ijms22062851 Text en © 2021 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Amarasekara, Dulshara Sachini Kim, Sumi Rho, Jaerang Regulation of Osteoblast Differentiation by Cytokine Networks |
title | Regulation of Osteoblast Differentiation by Cytokine Networks |
title_full | Regulation of Osteoblast Differentiation by Cytokine Networks |
title_fullStr | Regulation of Osteoblast Differentiation by Cytokine Networks |
title_full_unstemmed | Regulation of Osteoblast Differentiation by Cytokine Networks |
title_short | Regulation of Osteoblast Differentiation by Cytokine Networks |
title_sort | regulation of osteoblast differentiation by cytokine networks |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7998677/ https://www.ncbi.nlm.nih.gov/pubmed/33799644 http://dx.doi.org/10.3390/ijms22062851 |
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