Successful Treatment of a Recalcitrant Staphylococcus epidermidis Prosthetic Knee Infection with Intraoperative Bacteriophage Therapy

Here, we present a case of a 79-year-old female with a recalcitrant Staphylococcal epidermidis prosthetic knee infection that was successfully treated with a single dose of adjuvant intra-articular bacteriophage therapy after debridement and implant retention surgery. The bacteriophage used in this...

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Autores principales: Doub, James B., Ng, Vincent Y., Wilson, Eleanor, Corsini, Lorenzo, Chan, Benjamin K.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7998749/
https://www.ncbi.nlm.nih.gov/pubmed/33800146
http://dx.doi.org/10.3390/ph14030231
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author Doub, James B.
Ng, Vincent Y.
Wilson, Eleanor
Corsini, Lorenzo
Chan, Benjamin K.
author_facet Doub, James B.
Ng, Vincent Y.
Wilson, Eleanor
Corsini, Lorenzo
Chan, Benjamin K.
author_sort Doub, James B.
collection PubMed
description Here, we present a case of a 79-year-old female with a recalcitrant Staphylococcal epidermidis prosthetic knee infection that was successfully treated with a single dose of adjuvant intra-articular bacteriophage therapy after debridement and implant retention surgery. The bacteriophage used in this case, PM448, is the first ɛ(2) bacteriophage to be used in vivo. Currently the patient is without evidence of clinical recurrence and, interestingly, the patient had also suffered from debilitating aplastic anemia for over 2 years, which is recovering since receiving adjuvant bacteriophage therapy.
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spelling pubmed-79987492021-03-28 Successful Treatment of a Recalcitrant Staphylococcus epidermidis Prosthetic Knee Infection with Intraoperative Bacteriophage Therapy Doub, James B. Ng, Vincent Y. Wilson, Eleanor Corsini, Lorenzo Chan, Benjamin K. Pharmaceuticals (Basel) Case Report Here, we present a case of a 79-year-old female with a recalcitrant Staphylococcal epidermidis prosthetic knee infection that was successfully treated with a single dose of adjuvant intra-articular bacteriophage therapy after debridement and implant retention surgery. The bacteriophage used in this case, PM448, is the first ɛ(2) bacteriophage to be used in vivo. Currently the patient is without evidence of clinical recurrence and, interestingly, the patient had also suffered from debilitating aplastic anemia for over 2 years, which is recovering since receiving adjuvant bacteriophage therapy. MDPI 2021-03-08 /pmc/articles/PMC7998749/ /pubmed/33800146 http://dx.doi.org/10.3390/ph14030231 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) ).
spellingShingle Case Report
Doub, James B.
Ng, Vincent Y.
Wilson, Eleanor
Corsini, Lorenzo
Chan, Benjamin K.
Successful Treatment of a Recalcitrant Staphylococcus epidermidis Prosthetic Knee Infection with Intraoperative Bacteriophage Therapy
title Successful Treatment of a Recalcitrant Staphylococcus epidermidis Prosthetic Knee Infection with Intraoperative Bacteriophage Therapy
title_full Successful Treatment of a Recalcitrant Staphylococcus epidermidis Prosthetic Knee Infection with Intraoperative Bacteriophage Therapy
title_fullStr Successful Treatment of a Recalcitrant Staphylococcus epidermidis Prosthetic Knee Infection with Intraoperative Bacteriophage Therapy
title_full_unstemmed Successful Treatment of a Recalcitrant Staphylococcus epidermidis Prosthetic Knee Infection with Intraoperative Bacteriophage Therapy
title_short Successful Treatment of a Recalcitrant Staphylococcus epidermidis Prosthetic Knee Infection with Intraoperative Bacteriophage Therapy
title_sort successful treatment of a recalcitrant staphylococcus epidermidis prosthetic knee infection with intraoperative bacteriophage therapy
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7998749/
https://www.ncbi.nlm.nih.gov/pubmed/33800146
http://dx.doi.org/10.3390/ph14030231
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