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Predictive Factors of the Responses to Treatment of Mycoplasma pneumoniae Pneumonia

The prevalence of refractory Mycoplasma pneumoniae (MP) pneumonia is increasing. The present study aimed to identify the predictive factors of responses to treatment of MP pneumonia in children. A total of 149 children were diagnosed with MP pneumonia, of whom 56 were included in the good response g...

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Autores principales: Lee, Eun, Lee, Yun Young
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7998824/
https://www.ncbi.nlm.nih.gov/pubmed/33801856
http://dx.doi.org/10.3390/jcm10061154
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author Lee, Eun
Lee, Yun Young
author_facet Lee, Eun
Lee, Yun Young
author_sort Lee, Eun
collection PubMed
description The prevalence of refractory Mycoplasma pneumoniae (MP) pneumonia is increasing. The present study aimed to identify the predictive factors of responses to treatment of MP pneumonia in children. A total of 149 children were diagnosed with MP pneumonia, of whom 56 were included in the good response group, 75 children in the slow response group, and 18 children in no response or progression group. Data on the clinical, laboratory, and radiologic features were retrospectively obtained through medical chart reviews. The severity of pneumonia, based on the extent of pneumonic lesions on chest x-ray (adjusted odds ratio (aOR), 10.573; 95% confidence intervals (CIs), 2.303−48.543), and lactate dehydrogenase (LDH) levels (aOR, 1.002; 95% CIs, 1.000–1.004) at the time of admission were associated with slow response to treatment of MP pneumonia. Pleural effusion (aOR, 5.127; 95% CIs, 1.404–18.727), respiratory virus co-infection (aOR, 4.354; 95% CIs, 1.374–13.800), and higher LDH levels (aOR, 1.005; 95% CIs, 1.002–1.007) as well as MP-specific IgM titer (aOR, 1.309; 95% CIs, 1.095–1.564) were associated with no response or progression of MP pneumonia. The area under the curve for the prediction of no or poor response in MP pneumonia using pleural effusion, respiratory virus co-infection, LDH levels, and MP-specific IgM titer at the time of admission was 0.8547. This study identified the predictive factors of responses to treatment of MP pneumonia in children, which would be helpful in establishing a therapeutic plan and predicting the clinical course of MP pneumonia in children.
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spelling pubmed-79988242021-03-28 Predictive Factors of the Responses to Treatment of Mycoplasma pneumoniae Pneumonia Lee, Eun Lee, Yun Young J Clin Med Article The prevalence of refractory Mycoplasma pneumoniae (MP) pneumonia is increasing. The present study aimed to identify the predictive factors of responses to treatment of MP pneumonia in children. A total of 149 children were diagnosed with MP pneumonia, of whom 56 were included in the good response group, 75 children in the slow response group, and 18 children in no response or progression group. Data on the clinical, laboratory, and radiologic features were retrospectively obtained through medical chart reviews. The severity of pneumonia, based on the extent of pneumonic lesions on chest x-ray (adjusted odds ratio (aOR), 10.573; 95% confidence intervals (CIs), 2.303−48.543), and lactate dehydrogenase (LDH) levels (aOR, 1.002; 95% CIs, 1.000–1.004) at the time of admission were associated with slow response to treatment of MP pneumonia. Pleural effusion (aOR, 5.127; 95% CIs, 1.404–18.727), respiratory virus co-infection (aOR, 4.354; 95% CIs, 1.374–13.800), and higher LDH levels (aOR, 1.005; 95% CIs, 1.002–1.007) as well as MP-specific IgM titer (aOR, 1.309; 95% CIs, 1.095–1.564) were associated with no response or progression of MP pneumonia. The area under the curve for the prediction of no or poor response in MP pneumonia using pleural effusion, respiratory virus co-infection, LDH levels, and MP-specific IgM titer at the time of admission was 0.8547. This study identified the predictive factors of responses to treatment of MP pneumonia in children, which would be helpful in establishing a therapeutic plan and predicting the clinical course of MP pneumonia in children. MDPI 2021-03-10 /pmc/articles/PMC7998824/ /pubmed/33801856 http://dx.doi.org/10.3390/jcm10061154 Text en © 2021 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Lee, Eun
Lee, Yun Young
Predictive Factors of the Responses to Treatment of Mycoplasma pneumoniae Pneumonia
title Predictive Factors of the Responses to Treatment of Mycoplasma pneumoniae Pneumonia
title_full Predictive Factors of the Responses to Treatment of Mycoplasma pneumoniae Pneumonia
title_fullStr Predictive Factors of the Responses to Treatment of Mycoplasma pneumoniae Pneumonia
title_full_unstemmed Predictive Factors of the Responses to Treatment of Mycoplasma pneumoniae Pneumonia
title_short Predictive Factors of the Responses to Treatment of Mycoplasma pneumoniae Pneumonia
title_sort predictive factors of the responses to treatment of mycoplasma pneumoniae pneumonia
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7998824/
https://www.ncbi.nlm.nih.gov/pubmed/33801856
http://dx.doi.org/10.3390/jcm10061154
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