Neuroendocrine Differentiation of Prostate Cancer Is Not Systematically Associated with Increased 18F-FDG Uptake

Neuroendocrine differentiation (NED) of prostate cancer represents an acknowledged predictor of resistant and more aggressive disease. NED can be functionally exploited in vivo using PET/CT imaging with somatostatin analogs radiolabeled with 68Ga. Many previous reports have shown that 18F-FDG PET/CT...

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Autores principales: Bauckneht, Matteo, Morbelli, Silvia, Miceli, Alberto, Rebuzzi, Sara Elena, Fornarini, Giuseppe
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Interesting Images
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7998830/
https://www.ncbi.nlm.nih.gov/pubmed/33800158
http://dx.doi.org/10.3390/diagnostics11030468
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author Bauckneht, Matteo
Morbelli, Silvia
Miceli, Alberto
Rebuzzi, Sara Elena
Fornarini, Giuseppe
author_facet Bauckneht, Matteo
Morbelli, Silvia
Miceli, Alberto
Rebuzzi, Sara Elena
Fornarini, Giuseppe
author_sort Bauckneht, Matteo
collection PubMed
description Neuroendocrine differentiation (NED) of prostate cancer represents an acknowledged predictor of resistant and more aggressive disease. NED can be functionally exploited in vivo using PET/CT imaging with somatostatin analogs radiolabeled with 68Ga. Many previous reports have shown that 18F-FDG PET/CT should also be used in cases such as guiding management, as NED is systematically associated with increased glycolysis. We hereby discuss the case of a metastatic prostate cancer patient in which 68Ga-Dotatoc PET/CT revealed the occurrence of NED with low FDG-avidity.
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spelling pubmed-79988302021-03-28 Neuroendocrine Differentiation of Prostate Cancer Is Not Systematically Associated with Increased 18F-FDG Uptake Bauckneht, Matteo Morbelli, Silvia Miceli, Alberto Rebuzzi, Sara Elena Fornarini, Giuseppe Diagnostics (Basel) Interesting Images Neuroendocrine differentiation (NED) of prostate cancer represents an acknowledged predictor of resistant and more aggressive disease. NED can be functionally exploited in vivo using PET/CT imaging with somatostatin analogs radiolabeled with 68Ga. Many previous reports have shown that 18F-FDG PET/CT should also be used in cases such as guiding management, as NED is systematically associated with increased glycolysis. We hereby discuss the case of a metastatic prostate cancer patient in which 68Ga-Dotatoc PET/CT revealed the occurrence of NED with low FDG-avidity. MDPI 2021-03-08 /pmc/articles/PMC7998830/ /pubmed/33800158 http://dx.doi.org/10.3390/diagnostics11030468 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) ).
spellingShingle Interesting Images
Bauckneht, Matteo
Morbelli, Silvia
Miceli, Alberto
Rebuzzi, Sara Elena
Fornarini, Giuseppe
Neuroendocrine Differentiation of Prostate Cancer Is Not Systematically Associated with Increased 18F-FDG Uptake
title Neuroendocrine Differentiation of Prostate Cancer Is Not Systematically Associated with Increased 18F-FDG Uptake
title_full Neuroendocrine Differentiation of Prostate Cancer Is Not Systematically Associated with Increased 18F-FDG Uptake
title_fullStr Neuroendocrine Differentiation of Prostate Cancer Is Not Systematically Associated with Increased 18F-FDG Uptake
title_full_unstemmed Neuroendocrine Differentiation of Prostate Cancer Is Not Systematically Associated with Increased 18F-FDG Uptake
title_short Neuroendocrine Differentiation of Prostate Cancer Is Not Systematically Associated with Increased 18F-FDG Uptake
title_sort neuroendocrine differentiation of prostate cancer is not systematically associated with increased 18f-fdg uptake
topic Interesting Images
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7998830/
https://www.ncbi.nlm.nih.gov/pubmed/33800158
http://dx.doi.org/10.3390/diagnostics11030468
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