Non-Albumin Proteinuria (NAP) as a Complementary Marker for Diabetic Kidney Disease (DKD)

Diabetic kidney disease (DKD) is one of the most common forms of chronic kidney disease. Its pathogenic mechanism is complex, and it can affect entire structures of the kidney. However, conventional approaches to early stage DKD have focused on changes to the glomerulus. Current standard screening t...

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Detalles Bibliográficos
Autores principales: Bae, Jaehyun, Won, Young Jun, Lee, Byung-Wan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7998887/
https://www.ncbi.nlm.nih.gov/pubmed/33802211
http://dx.doi.org/10.3390/life11030224
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author Bae, Jaehyun
Won, Young Jun
Lee, Byung-Wan
author_facet Bae, Jaehyun
Won, Young Jun
Lee, Byung-Wan
author_sort Bae, Jaehyun
collection PubMed
description Diabetic kidney disease (DKD) is one of the most common forms of chronic kidney disease. Its pathogenic mechanism is complex, and it can affect entire structures of the kidney. However, conventional approaches to early stage DKD have focused on changes to the glomerulus. Current standard screening tools for DKD, albuminuria, and estimated glomerular filtration rate are insufficient to reflect early tubular injury. Therefore, many tubular biomarkers have been suggested. Non-albumin proteinuria (NAP) contains a wide range of tubular biomarkers and is convenient to measure. We reviewed the clinical meanings of NAP and its significance as a marker for early stage DKD.
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spelling pubmed-79988872021-03-28 Non-Albumin Proteinuria (NAP) as a Complementary Marker for Diabetic Kidney Disease (DKD) Bae, Jaehyun Won, Young Jun Lee, Byung-Wan Life (Basel) Review Diabetic kidney disease (DKD) is one of the most common forms of chronic kidney disease. Its pathogenic mechanism is complex, and it can affect entire structures of the kidney. However, conventional approaches to early stage DKD have focused on changes to the glomerulus. Current standard screening tools for DKD, albuminuria, and estimated glomerular filtration rate are insufficient to reflect early tubular injury. Therefore, many tubular biomarkers have been suggested. Non-albumin proteinuria (NAP) contains a wide range of tubular biomarkers and is convenient to measure. We reviewed the clinical meanings of NAP and its significance as a marker for early stage DKD. MDPI 2021-03-10 /pmc/articles/PMC7998887/ /pubmed/33802211 http://dx.doi.org/10.3390/life11030224 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) ).
spellingShingle Review
Bae, Jaehyun
Won, Young Jun
Lee, Byung-Wan
Non-Albumin Proteinuria (NAP) as a Complementary Marker for Diabetic Kidney Disease (DKD)
title Non-Albumin Proteinuria (NAP) as a Complementary Marker for Diabetic Kidney Disease (DKD)
title_full Non-Albumin Proteinuria (NAP) as a Complementary Marker for Diabetic Kidney Disease (DKD)
title_fullStr Non-Albumin Proteinuria (NAP) as a Complementary Marker for Diabetic Kidney Disease (DKD)
title_full_unstemmed Non-Albumin Proteinuria (NAP) as a Complementary Marker for Diabetic Kidney Disease (DKD)
title_short Non-Albumin Proteinuria (NAP) as a Complementary Marker for Diabetic Kidney Disease (DKD)
title_sort non-albumin proteinuria (nap) as a complementary marker for diabetic kidney disease (dkd)
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7998887/
https://www.ncbi.nlm.nih.gov/pubmed/33802211
http://dx.doi.org/10.3390/life11030224
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AT leebyungwan nonalbuminproteinurianapasacomplementarymarkerfordiabetickidneydiseasedkd

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