Cargando…

Optical Platform to Analyze a Model Drug-Loading and Releasing Profile Based on Nanoporous Anodic Alumina Gradient Index Filters

In this work, a methodology that exploits the optical properties of the nanoporous anodic alumina gradient index filters (NAA-GIFs) has been developed and applied to evaluate in real time the release dynamics of a cargo molecule, acting as a model drug, filling the pores. NAA-GIFs with two photonic...

Descripción completa

Detalles Bibliográficos
Autores principales: Kapruwan, Pankaj, Acosta, Laura K., Ferré-Borrull, Josep, Marsal, Lluis F.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7998892/
https://www.ncbi.nlm.nih.gov/pubmed/33799415
http://dx.doi.org/10.3390/nano11030730
_version_ 1783670657056243712
author Kapruwan, Pankaj
Acosta, Laura K.
Ferré-Borrull, Josep
Marsal, Lluis F.
author_facet Kapruwan, Pankaj
Acosta, Laura K.
Ferré-Borrull, Josep
Marsal, Lluis F.
author_sort Kapruwan, Pankaj
collection PubMed
description In this work, a methodology that exploits the optical properties of the nanoporous anodic alumina gradient index filters (NAA-GIFs) has been developed and applied to evaluate in real time the release dynamics of a cargo molecule, acting as a model drug, filling the pores. NAA-GIFs with two photonic stopbands (PSBs) were prepared with one of its stop bands in the same absorption wavelength range of the cargo molecule, whereas the second stopband away from this absorption range. Numerical simulation and experiments confirm that the relative height of the high reflectance bands in the reflectance spectra of NAA-GIFs filled with the drug can be related to the relative amount of drug filling the pores. This property has been applied in a flow cell setup to measure in real-time the release dynamics of NAA-GIFs with the inner pore surface modified by layer-by-layer deposition of polyelectrolytes and loaded with the cargo molecule. The methodology developed in this work acts as a tool for the study of drug delivery from porous nanostructures.
format Online
Article
Text
id pubmed-7998892
institution National Center for Biotechnology Information
language English
publishDate 2021
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-79988922021-03-28 Optical Platform to Analyze a Model Drug-Loading and Releasing Profile Based on Nanoporous Anodic Alumina Gradient Index Filters Kapruwan, Pankaj Acosta, Laura K. Ferré-Borrull, Josep Marsal, Lluis F. Nanomaterials (Basel) Article In this work, a methodology that exploits the optical properties of the nanoporous anodic alumina gradient index filters (NAA-GIFs) has been developed and applied to evaluate in real time the release dynamics of a cargo molecule, acting as a model drug, filling the pores. NAA-GIFs with two photonic stopbands (PSBs) were prepared with one of its stop bands in the same absorption wavelength range of the cargo molecule, whereas the second stopband away from this absorption range. Numerical simulation and experiments confirm that the relative height of the high reflectance bands in the reflectance spectra of NAA-GIFs filled with the drug can be related to the relative amount of drug filling the pores. This property has been applied in a flow cell setup to measure in real-time the release dynamics of NAA-GIFs with the inner pore surface modified by layer-by-layer deposition of polyelectrolytes and loaded with the cargo molecule. The methodology developed in this work acts as a tool for the study of drug delivery from porous nanostructures. MDPI 2021-03-14 /pmc/articles/PMC7998892/ /pubmed/33799415 http://dx.doi.org/10.3390/nano11030730 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) ).
spellingShingle Article
Kapruwan, Pankaj
Acosta, Laura K.
Ferré-Borrull, Josep
Marsal, Lluis F.
Optical Platform to Analyze a Model Drug-Loading and Releasing Profile Based on Nanoporous Anodic Alumina Gradient Index Filters
title Optical Platform to Analyze a Model Drug-Loading and Releasing Profile Based on Nanoporous Anodic Alumina Gradient Index Filters
title_full Optical Platform to Analyze a Model Drug-Loading and Releasing Profile Based on Nanoporous Anodic Alumina Gradient Index Filters
title_fullStr Optical Platform to Analyze a Model Drug-Loading and Releasing Profile Based on Nanoporous Anodic Alumina Gradient Index Filters
title_full_unstemmed Optical Platform to Analyze a Model Drug-Loading and Releasing Profile Based on Nanoporous Anodic Alumina Gradient Index Filters
title_short Optical Platform to Analyze a Model Drug-Loading and Releasing Profile Based on Nanoporous Anodic Alumina Gradient Index Filters
title_sort optical platform to analyze a model drug-loading and releasing profile based on nanoporous anodic alumina gradient index filters
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7998892/
https://www.ncbi.nlm.nih.gov/pubmed/33799415
http://dx.doi.org/10.3390/nano11030730
work_keys_str_mv AT kapruwanpankaj opticalplatformtoanalyzeamodeldrugloadingandreleasingprofilebasedonnanoporousanodicaluminagradientindexfilters
AT acostalaurak opticalplatformtoanalyzeamodeldrugloadingandreleasingprofilebasedonnanoporousanodicaluminagradientindexfilters
AT ferreborrulljosep opticalplatformtoanalyzeamodeldrugloadingandreleasingprofilebasedonnanoporousanodicaluminagradientindexfilters
AT marsallluisf opticalplatformtoanalyzeamodeldrugloadingandreleasingprofilebasedonnanoporousanodicaluminagradientindexfilters