JNK and p38 Inhibitors Prevent Transforming Growth Factor-β1-Induced Myofibroblast Transdifferentiation in Human Graves’ Orbital Fibroblasts

Transforming growth factor-β1 (TGF-β1)-induced myofibroblast transdifferentiation from orbital fibroblasts is known to dominate tissue remodeling and fibrosis in Graves’ ophthalmopathy (GO). However, the signaling pathways through which TGF-β1 activates Graves’ orbital fibroblasts remain unclear. Th...

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Detalles Bibliográficos
Autores principales: Hou, Tzu-Yu, Wu, Shi-Bei, Kau, Hui-Chuan, Tsai, Chieh-Chih
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7998969/
https://www.ncbi.nlm.nih.gov/pubmed/33799469
http://dx.doi.org/10.3390/ijms22062952

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7998969/
https://www.ncbi.nlm.nih.gov/pubmed/33799469
http://dx.doi.org/10.3390/ijms22062952

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