The eTRANSAFE Project on Translational Safety Assessment through Integrative Knowledge Management: Achievements and Perspectives

eTRANSAFE is a research project funded within the Innovative Medicines Initiative (IMI), which aims at developing integrated databases and computational tools (the eTRANSAFE ToxHub) that support the translational safety assessment of new drugs by using legacy data provided by the pharmaceutical comp...

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Autores principales: Pognan, François, Steger-Hartmann, Thomas, Díaz, Carlos, Blomberg, Niklas, Bringezu, Frank, Briggs, Katharine, Callegaro, Giulia, Capella-Gutierrez, Salvador, Centeno, Emilio, Corvi, Javier, Drew, Philip, Drewe, William C., Fernández, José M., Furlong, Laura I., Guney, Emre, Kors, Jan A., Mayer, Miguel Angel, Pastor, Manuel, Piñero, Janet, Ramírez-Anguita, Juan Manuel, Ronzano, Francesco, Rowell, Philip, Saüch-Pitarch, Josep, Valencia, Alfonso, van de Water, Bob, van der Lei, Johan, van Mulligen, Erik, Sanz, Ferran
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7999019/
https://www.ncbi.nlm.nih.gov/pubmed/33800393
http://dx.doi.org/10.3390/ph14030237
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author Pognan, François
Steger-Hartmann, Thomas
Díaz, Carlos
Blomberg, Niklas
Bringezu, Frank
Briggs, Katharine
Callegaro, Giulia
Capella-Gutierrez, Salvador
Centeno, Emilio
Corvi, Javier
Drew, Philip
Drewe, William C.
Fernández, José M.
Furlong, Laura I.
Guney, Emre
Kors, Jan A.
Mayer, Miguel Angel
Pastor, Manuel
Piñero, Janet
Ramírez-Anguita, Juan Manuel
Ronzano, Francesco
Rowell, Philip
Saüch-Pitarch, Josep
Valencia, Alfonso
van de Water, Bob
van der Lei, Johan
van Mulligen, Erik
Sanz, Ferran
author_facet Pognan, François
Steger-Hartmann, Thomas
Díaz, Carlos
Blomberg, Niklas
Bringezu, Frank
Briggs, Katharine
Callegaro, Giulia
Capella-Gutierrez, Salvador
Centeno, Emilio
Corvi, Javier
Drew, Philip
Drewe, William C.
Fernández, José M.
Furlong, Laura I.
Guney, Emre
Kors, Jan A.
Mayer, Miguel Angel
Pastor, Manuel
Piñero, Janet
Ramírez-Anguita, Juan Manuel
Ronzano, Francesco
Rowell, Philip
Saüch-Pitarch, Josep
Valencia, Alfonso
van de Water, Bob
van der Lei, Johan
van Mulligen, Erik
Sanz, Ferran
author_sort Pognan, François
collection PubMed
description eTRANSAFE is a research project funded within the Innovative Medicines Initiative (IMI), which aims at developing integrated databases and computational tools (the eTRANSAFE ToxHub) that support the translational safety assessment of new drugs by using legacy data provided by the pharmaceutical companies that participate in the project. The project objectives include the development of databases containing preclinical and clinical data, computational systems for translational analysis including tools for data query, analysis and visualization, as well as computational models to explain and predict drug safety events.
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spelling pubmed-79990192021-03-28 The eTRANSAFE Project on Translational Safety Assessment through Integrative Knowledge Management: Achievements and Perspectives Pognan, François Steger-Hartmann, Thomas Díaz, Carlos Blomberg, Niklas Bringezu, Frank Briggs, Katharine Callegaro, Giulia Capella-Gutierrez, Salvador Centeno, Emilio Corvi, Javier Drew, Philip Drewe, William C. Fernández, José M. Furlong, Laura I. Guney, Emre Kors, Jan A. Mayer, Miguel Angel Pastor, Manuel Piñero, Janet Ramírez-Anguita, Juan Manuel Ronzano, Francesco Rowell, Philip Saüch-Pitarch, Josep Valencia, Alfonso van de Water, Bob van der Lei, Johan van Mulligen, Erik Sanz, Ferran Pharmaceuticals (Basel) Article eTRANSAFE is a research project funded within the Innovative Medicines Initiative (IMI), which aims at developing integrated databases and computational tools (the eTRANSAFE ToxHub) that support the translational safety assessment of new drugs by using legacy data provided by the pharmaceutical companies that participate in the project. The project objectives include the development of databases containing preclinical and clinical data, computational systems for translational analysis including tools for data query, analysis and visualization, as well as computational models to explain and predict drug safety events. MDPI 2021-03-08 /pmc/articles/PMC7999019/ /pubmed/33800393 http://dx.doi.org/10.3390/ph14030237 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) ).
spellingShingle Article
Pognan, François
Steger-Hartmann, Thomas
Díaz, Carlos
Blomberg, Niklas
Bringezu, Frank
Briggs, Katharine
Callegaro, Giulia
Capella-Gutierrez, Salvador
Centeno, Emilio
Corvi, Javier
Drew, Philip
Drewe, William C.
Fernández, José M.
Furlong, Laura I.
Guney, Emre
Kors, Jan A.
Mayer, Miguel Angel
Pastor, Manuel
Piñero, Janet
Ramírez-Anguita, Juan Manuel
Ronzano, Francesco
Rowell, Philip
Saüch-Pitarch, Josep
Valencia, Alfonso
van de Water, Bob
van der Lei, Johan
van Mulligen, Erik
Sanz, Ferran
The eTRANSAFE Project on Translational Safety Assessment through Integrative Knowledge Management: Achievements and Perspectives
title The eTRANSAFE Project on Translational Safety Assessment through Integrative Knowledge Management: Achievements and Perspectives
title_full The eTRANSAFE Project on Translational Safety Assessment through Integrative Knowledge Management: Achievements and Perspectives
title_fullStr The eTRANSAFE Project on Translational Safety Assessment through Integrative Knowledge Management: Achievements and Perspectives
title_full_unstemmed The eTRANSAFE Project on Translational Safety Assessment through Integrative Knowledge Management: Achievements and Perspectives
title_short The eTRANSAFE Project on Translational Safety Assessment through Integrative Knowledge Management: Achievements and Perspectives
title_sort etransafe project on translational safety assessment through integrative knowledge management: achievements and perspectives
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7999019/
https://www.ncbi.nlm.nih.gov/pubmed/33800393
http://dx.doi.org/10.3390/ph14030237
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