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Association of Hemoglobin and Hematocrit Levels during Pregnancy and Maternal Dietary Iron Intake with Allergic Diseases in Children: The Japan Environment and Children’s Study (JECS)

Few epidemiologic studies have examined the role of maternal iron status in allergic diseases in offspring and findings have been inconsistent. We used a large birth cohort in Japan to explore the association of the markers for maternal iron status (maternal hemoglobin, hematocrit and dietary iron i...

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Autores principales: Yang, Limin, Sato, Miori, Saito-Abe, Mayako, Irahara, Makoto, Nishizato, Minaho, Sasaki, Hatoko, Konishi, Mizuho, Ishitsuka, Kazue, Mezawa, Hidetoshi, Yamamoto-Hanada, Kiwako, Matsumoto, Kenji, Ohya, Yukihiro
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7999127/
https://www.ncbi.nlm.nih.gov/pubmed/33804474
http://dx.doi.org/10.3390/nu13030810
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author Yang, Limin
Sato, Miori
Saito-Abe, Mayako
Irahara, Makoto
Nishizato, Minaho
Sasaki, Hatoko
Konishi, Mizuho
Ishitsuka, Kazue
Mezawa, Hidetoshi
Yamamoto-Hanada, Kiwako
Matsumoto, Kenji
Ohya, Yukihiro
author_facet Yang, Limin
Sato, Miori
Saito-Abe, Mayako
Irahara, Makoto
Nishizato, Minaho
Sasaki, Hatoko
Konishi, Mizuho
Ishitsuka, Kazue
Mezawa, Hidetoshi
Yamamoto-Hanada, Kiwako
Matsumoto, Kenji
Ohya, Yukihiro
author_sort Yang, Limin
collection PubMed
description Few epidemiologic studies have examined the role of maternal iron status in allergic diseases in offspring and findings have been inconsistent. We used a large birth cohort in Japan to explore the association of the markers for maternal iron status (maternal hemoglobin, hematocrit and dietary iron intake during pregnancy) with allergy development in offspring during early childhood. We analyzed information on children age 0–3 years from the Japan Environment and Children’s Study (JECS). We used logistic models and generalized estimating equation models to evaluate the effect of maternal hemoglobin and hematocrit levels and dietary iron intake on allergies in children. Models were also fitted with propensity score-matched datasets. Data were collected for a total of 91,247 mother–child pairs. The prevalence (95% confidence interval) of low hemoglobin and hematocrit was 14.0% (13.7–14.2%) and 12.5% (12.3–12.8%), respectively. After adjusting confounders, low hemoglobin and hematocrit during pregnancy were not associated with childhood allergic outcomes. Findings from models with propensity score-matched datasets also indicated that children born to mothers with low hemoglobin or hematocrit levels during pregnancy did not have a higher risk of developing allergic conditions at 3 years old. We found no meaningful associations between low energy adjusted maternal dietary iron intake and allergies in children. In conclusion, using birth cohort data, we found no evidence supporting an association of low maternal hemoglobin, hematocrit and low dietary iron intake with allergy symptoms during early childhood. Further studies with more suitable proxy markers for blood iron status are needed.
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spelling pubmed-79991272021-03-28 Association of Hemoglobin and Hematocrit Levels during Pregnancy and Maternal Dietary Iron Intake with Allergic Diseases in Children: The Japan Environment and Children’s Study (JECS) Yang, Limin Sato, Miori Saito-Abe, Mayako Irahara, Makoto Nishizato, Minaho Sasaki, Hatoko Konishi, Mizuho Ishitsuka, Kazue Mezawa, Hidetoshi Yamamoto-Hanada, Kiwako Matsumoto, Kenji Ohya, Yukihiro Nutrients Article Few epidemiologic studies have examined the role of maternal iron status in allergic diseases in offspring and findings have been inconsistent. We used a large birth cohort in Japan to explore the association of the markers for maternal iron status (maternal hemoglobin, hematocrit and dietary iron intake during pregnancy) with allergy development in offspring during early childhood. We analyzed information on children age 0–3 years from the Japan Environment and Children’s Study (JECS). We used logistic models and generalized estimating equation models to evaluate the effect of maternal hemoglobin and hematocrit levels and dietary iron intake on allergies in children. Models were also fitted with propensity score-matched datasets. Data were collected for a total of 91,247 mother–child pairs. The prevalence (95% confidence interval) of low hemoglobin and hematocrit was 14.0% (13.7–14.2%) and 12.5% (12.3–12.8%), respectively. After adjusting confounders, low hemoglobin and hematocrit during pregnancy were not associated with childhood allergic outcomes. Findings from models with propensity score-matched datasets also indicated that children born to mothers with low hemoglobin or hematocrit levels during pregnancy did not have a higher risk of developing allergic conditions at 3 years old. We found no meaningful associations between low energy adjusted maternal dietary iron intake and allergies in children. In conclusion, using birth cohort data, we found no evidence supporting an association of low maternal hemoglobin, hematocrit and low dietary iron intake with allergy symptoms during early childhood. Further studies with more suitable proxy markers for blood iron status are needed. MDPI 2021-03-01 /pmc/articles/PMC7999127/ /pubmed/33804474 http://dx.doi.org/10.3390/nu13030810 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) ).
spellingShingle Article
Yang, Limin
Sato, Miori
Saito-Abe, Mayako
Irahara, Makoto
Nishizato, Minaho
Sasaki, Hatoko
Konishi, Mizuho
Ishitsuka, Kazue
Mezawa, Hidetoshi
Yamamoto-Hanada, Kiwako
Matsumoto, Kenji
Ohya, Yukihiro
Association of Hemoglobin and Hematocrit Levels during Pregnancy and Maternal Dietary Iron Intake with Allergic Diseases in Children: The Japan Environment and Children’s Study (JECS)
title Association of Hemoglobin and Hematocrit Levels during Pregnancy and Maternal Dietary Iron Intake with Allergic Diseases in Children: The Japan Environment and Children’s Study (JECS)
title_full Association of Hemoglobin and Hematocrit Levels during Pregnancy and Maternal Dietary Iron Intake with Allergic Diseases in Children: The Japan Environment and Children’s Study (JECS)
title_fullStr Association of Hemoglobin and Hematocrit Levels during Pregnancy and Maternal Dietary Iron Intake with Allergic Diseases in Children: The Japan Environment and Children’s Study (JECS)
title_full_unstemmed Association of Hemoglobin and Hematocrit Levels during Pregnancy and Maternal Dietary Iron Intake with Allergic Diseases in Children: The Japan Environment and Children’s Study (JECS)
title_short Association of Hemoglobin and Hematocrit Levels during Pregnancy and Maternal Dietary Iron Intake with Allergic Diseases in Children: The Japan Environment and Children’s Study (JECS)
title_sort association of hemoglobin and hematocrit levels during pregnancy and maternal dietary iron intake with allergic diseases in children: the japan environment and children’s study (jecs)
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7999127/
https://www.ncbi.nlm.nih.gov/pubmed/33804474
http://dx.doi.org/10.3390/nu13030810
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