The Role of the Gut Microbiota in the Gut–Brain Axis in Obesity: Mechanisms and Future Implications

Interaction between the gut and the brain is essential for energy homeostasis. In obesity, this homeostasis is disrupted, leading to a positive energy balance and weight gain. Obesity is a global epidemic that affects individual health and strains the socioeconomic system. Microbial dysbiosis has lo...

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Autores principales: van Son, Jamie, Koekkoek, Laura L., La Fleur, Susanne E., Serlie, Mireille J., Nieuwdorp, Max
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7999163/
https://www.ncbi.nlm.nih.gov/pubmed/33804250
http://dx.doi.org/10.3390/ijms22062993
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author van Son, Jamie
Koekkoek, Laura L.
La Fleur, Susanne E.
Serlie, Mireille J.
Nieuwdorp, Max
author_facet van Son, Jamie
Koekkoek, Laura L.
La Fleur, Susanne E.
Serlie, Mireille J.
Nieuwdorp, Max
author_sort van Son, Jamie
collection PubMed
description Interaction between the gut and the brain is essential for energy homeostasis. In obesity, this homeostasis is disrupted, leading to a positive energy balance and weight gain. Obesity is a global epidemic that affects individual health and strains the socioeconomic system. Microbial dysbiosis has long been reported in obesity and obesity-related disorders. More recent literature has focused on the interaction of the gut microbiota and its metabolites on human brain and behavior. Developing strategies that target the gut microbiota could be a future approach for the treatment of obesity. Here, we review the microbiota–gut–brain axis and possible therapeutic options.
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spelling pubmed-79991632021-03-28 The Role of the Gut Microbiota in the Gut–Brain Axis in Obesity: Mechanisms and Future Implications van Son, Jamie Koekkoek, Laura L. La Fleur, Susanne E. Serlie, Mireille J. Nieuwdorp, Max Int J Mol Sci Review Interaction between the gut and the brain is essential for energy homeostasis. In obesity, this homeostasis is disrupted, leading to a positive energy balance and weight gain. Obesity is a global epidemic that affects individual health and strains the socioeconomic system. Microbial dysbiosis has long been reported in obesity and obesity-related disorders. More recent literature has focused on the interaction of the gut microbiota and its metabolites on human brain and behavior. Developing strategies that target the gut microbiota could be a future approach for the treatment of obesity. Here, we review the microbiota–gut–brain axis and possible therapeutic options. MDPI 2021-03-15 /pmc/articles/PMC7999163/ /pubmed/33804250 http://dx.doi.org/10.3390/ijms22062993 Text en © 2021 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
van Son, Jamie
Koekkoek, Laura L.
La Fleur, Susanne E.
Serlie, Mireille J.
Nieuwdorp, Max
The Role of the Gut Microbiota in the Gut–Brain Axis in Obesity: Mechanisms and Future Implications
title The Role of the Gut Microbiota in the Gut–Brain Axis in Obesity: Mechanisms and Future Implications
title_full The Role of the Gut Microbiota in the Gut–Brain Axis in Obesity: Mechanisms and Future Implications
title_fullStr The Role of the Gut Microbiota in the Gut–Brain Axis in Obesity: Mechanisms and Future Implications
title_full_unstemmed The Role of the Gut Microbiota in the Gut–Brain Axis in Obesity: Mechanisms and Future Implications
title_short The Role of the Gut Microbiota in the Gut–Brain Axis in Obesity: Mechanisms and Future Implications
title_sort role of the gut microbiota in the gut–brain axis in obesity: mechanisms and future implications
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7999163/
https://www.ncbi.nlm.nih.gov/pubmed/33804250
http://dx.doi.org/10.3390/ijms22062993
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