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Vertical Transmission of SARS-CoV-2 in Second Trimester Associated with Severe Neonatal Pathology

The effects of severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) infection in women on the gestation course and the health of the fetus, particularly in the first and second trimesters, remain very poorly explored. This report describes a case in which the normal development of pregnancy...

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Autores principales: Sukhikh, Gennady, Petrova, Ulyana, Prikhodko, Andrey, Starodubtseva, Natalia, Chingin, Konstantin, Chen, Huanwen, Bugrova, Anna, Kononikhin, Alexey, Bourmenskaya, Olga, Brzhozovskiy, Alexander, Polushkina, Evgeniya, Kulikova, Galina, Shchegolev, Alexander, Trofimov, Dmitry, Frankevich, Vladimir, Nikolaev, Evgeny, Shmakov, Roman G.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7999228/
https://www.ncbi.nlm.nih.gov/pubmed/33801923
http://dx.doi.org/10.3390/v13030447
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author Sukhikh, Gennady
Petrova, Ulyana
Prikhodko, Andrey
Starodubtseva, Natalia
Chingin, Konstantin
Chen, Huanwen
Bugrova, Anna
Kononikhin, Alexey
Bourmenskaya, Olga
Brzhozovskiy, Alexander
Polushkina, Evgeniya
Kulikova, Galina
Shchegolev, Alexander
Trofimov, Dmitry
Frankevich, Vladimir
Nikolaev, Evgeny
Shmakov, Roman G.
author_facet Sukhikh, Gennady
Petrova, Ulyana
Prikhodko, Andrey
Starodubtseva, Natalia
Chingin, Konstantin
Chen, Huanwen
Bugrova, Anna
Kononikhin, Alexey
Bourmenskaya, Olga
Brzhozovskiy, Alexander
Polushkina, Evgeniya
Kulikova, Galina
Shchegolev, Alexander
Trofimov, Dmitry
Frankevich, Vladimir
Nikolaev, Evgeny
Shmakov, Roman G.
author_sort Sukhikh, Gennady
collection PubMed
description The effects of severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) infection in women on the gestation course and the health of the fetus, particularly in the first and second trimesters, remain very poorly explored. This report describes a case in which the normal development of pregnancy was complicated immediately after the patient had experienced Coronavirus disease 2019 (COVID-19) at the 21st week of gestation. Specific conditions included critical blood flow in the fetal umbilical artery, fetal growth restriction (1st percentile), right ventricular hypertrophy, hydropericardium, echo-characteristics of hypoxic-ischemic brain injury (leukomalacia in periventricular area) and intraventricular hemorrhage at the 25th week of gestation. Premature male neonate delivered at the 26th week of gestation died after 1 day 18 h due to asystole. The results of independent polymerase chain reaction (PCR), mass spectrometry and immunohistochemistry analyses of placenta tissue, umbilical cord blood and child blood jointly indicated vertical transmission of SARS–CoV-2 from mother to the fetus, which we conclude to be the major cause for the development of maternal vascular malperfusion in the studied case.
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spelling pubmed-79992282021-03-28 Vertical Transmission of SARS-CoV-2 in Second Trimester Associated with Severe Neonatal Pathology Sukhikh, Gennady Petrova, Ulyana Prikhodko, Andrey Starodubtseva, Natalia Chingin, Konstantin Chen, Huanwen Bugrova, Anna Kononikhin, Alexey Bourmenskaya, Olga Brzhozovskiy, Alexander Polushkina, Evgeniya Kulikova, Galina Shchegolev, Alexander Trofimov, Dmitry Frankevich, Vladimir Nikolaev, Evgeny Shmakov, Roman G. Viruses Case Report The effects of severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) infection in women on the gestation course and the health of the fetus, particularly in the first and second trimesters, remain very poorly explored. This report describes a case in which the normal development of pregnancy was complicated immediately after the patient had experienced Coronavirus disease 2019 (COVID-19) at the 21st week of gestation. Specific conditions included critical blood flow in the fetal umbilical artery, fetal growth restriction (1st percentile), right ventricular hypertrophy, hydropericardium, echo-characteristics of hypoxic-ischemic brain injury (leukomalacia in periventricular area) and intraventricular hemorrhage at the 25th week of gestation. Premature male neonate delivered at the 26th week of gestation died after 1 day 18 h due to asystole. The results of independent polymerase chain reaction (PCR), mass spectrometry and immunohistochemistry analyses of placenta tissue, umbilical cord blood and child blood jointly indicated vertical transmission of SARS–CoV-2 from mother to the fetus, which we conclude to be the major cause for the development of maternal vascular malperfusion in the studied case. MDPI 2021-03-10 /pmc/articles/PMC7999228/ /pubmed/33801923 http://dx.doi.org/10.3390/v13030447 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) ).
spellingShingle Case Report
Sukhikh, Gennady
Petrova, Ulyana
Prikhodko, Andrey
Starodubtseva, Natalia
Chingin, Konstantin
Chen, Huanwen
Bugrova, Anna
Kononikhin, Alexey
Bourmenskaya, Olga
Brzhozovskiy, Alexander
Polushkina, Evgeniya
Kulikova, Galina
Shchegolev, Alexander
Trofimov, Dmitry
Frankevich, Vladimir
Nikolaev, Evgeny
Shmakov, Roman G.
Vertical Transmission of SARS-CoV-2 in Second Trimester Associated with Severe Neonatal Pathology
title Vertical Transmission of SARS-CoV-2 in Second Trimester Associated with Severe Neonatal Pathology
title_full Vertical Transmission of SARS-CoV-2 in Second Trimester Associated with Severe Neonatal Pathology
title_fullStr Vertical Transmission of SARS-CoV-2 in Second Trimester Associated with Severe Neonatal Pathology
title_full_unstemmed Vertical Transmission of SARS-CoV-2 in Second Trimester Associated with Severe Neonatal Pathology
title_short Vertical Transmission of SARS-CoV-2 in Second Trimester Associated with Severe Neonatal Pathology
title_sort vertical transmission of sars-cov-2 in second trimester associated with severe neonatal pathology
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7999228/
https://www.ncbi.nlm.nih.gov/pubmed/33801923
http://dx.doi.org/10.3390/v13030447
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