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Vertical Transmission of SARS-CoV-2 in Second Trimester Associated with Severe Neonatal Pathology
The effects of severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) infection in women on the gestation course and the health of the fetus, particularly in the first and second trimesters, remain very poorly explored. This report describes a case in which the normal development of pregnancy...
Autores principales: | , , , , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7999228/ https://www.ncbi.nlm.nih.gov/pubmed/33801923 http://dx.doi.org/10.3390/v13030447 |
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author | Sukhikh, Gennady Petrova, Ulyana Prikhodko, Andrey Starodubtseva, Natalia Chingin, Konstantin Chen, Huanwen Bugrova, Anna Kononikhin, Alexey Bourmenskaya, Olga Brzhozovskiy, Alexander Polushkina, Evgeniya Kulikova, Galina Shchegolev, Alexander Trofimov, Dmitry Frankevich, Vladimir Nikolaev, Evgeny Shmakov, Roman G. |
author_facet | Sukhikh, Gennady Petrova, Ulyana Prikhodko, Andrey Starodubtseva, Natalia Chingin, Konstantin Chen, Huanwen Bugrova, Anna Kononikhin, Alexey Bourmenskaya, Olga Brzhozovskiy, Alexander Polushkina, Evgeniya Kulikova, Galina Shchegolev, Alexander Trofimov, Dmitry Frankevich, Vladimir Nikolaev, Evgeny Shmakov, Roman G. |
author_sort | Sukhikh, Gennady |
collection | PubMed |
description | The effects of severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) infection in women on the gestation course and the health of the fetus, particularly in the first and second trimesters, remain very poorly explored. This report describes a case in which the normal development of pregnancy was complicated immediately after the patient had experienced Coronavirus disease 2019 (COVID-19) at the 21st week of gestation. Specific conditions included critical blood flow in the fetal umbilical artery, fetal growth restriction (1st percentile), right ventricular hypertrophy, hydropericardium, echo-characteristics of hypoxic-ischemic brain injury (leukomalacia in periventricular area) and intraventricular hemorrhage at the 25th week of gestation. Premature male neonate delivered at the 26th week of gestation died after 1 day 18 h due to asystole. The results of independent polymerase chain reaction (PCR), mass spectrometry and immunohistochemistry analyses of placenta tissue, umbilical cord blood and child blood jointly indicated vertical transmission of SARS–CoV-2 from mother to the fetus, which we conclude to be the major cause for the development of maternal vascular malperfusion in the studied case. |
format | Online Article Text |
id | pubmed-7999228 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-79992282021-03-28 Vertical Transmission of SARS-CoV-2 in Second Trimester Associated with Severe Neonatal Pathology Sukhikh, Gennady Petrova, Ulyana Prikhodko, Andrey Starodubtseva, Natalia Chingin, Konstantin Chen, Huanwen Bugrova, Anna Kononikhin, Alexey Bourmenskaya, Olga Brzhozovskiy, Alexander Polushkina, Evgeniya Kulikova, Galina Shchegolev, Alexander Trofimov, Dmitry Frankevich, Vladimir Nikolaev, Evgeny Shmakov, Roman G. Viruses Case Report The effects of severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) infection in women on the gestation course and the health of the fetus, particularly in the first and second trimesters, remain very poorly explored. This report describes a case in which the normal development of pregnancy was complicated immediately after the patient had experienced Coronavirus disease 2019 (COVID-19) at the 21st week of gestation. Specific conditions included critical blood flow in the fetal umbilical artery, fetal growth restriction (1st percentile), right ventricular hypertrophy, hydropericardium, echo-characteristics of hypoxic-ischemic brain injury (leukomalacia in periventricular area) and intraventricular hemorrhage at the 25th week of gestation. Premature male neonate delivered at the 26th week of gestation died after 1 day 18 h due to asystole. The results of independent polymerase chain reaction (PCR), mass spectrometry and immunohistochemistry analyses of placenta tissue, umbilical cord blood and child blood jointly indicated vertical transmission of SARS–CoV-2 from mother to the fetus, which we conclude to be the major cause for the development of maternal vascular malperfusion in the studied case. MDPI 2021-03-10 /pmc/articles/PMC7999228/ /pubmed/33801923 http://dx.doi.org/10.3390/v13030447 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) ). |
spellingShingle | Case Report Sukhikh, Gennady Petrova, Ulyana Prikhodko, Andrey Starodubtseva, Natalia Chingin, Konstantin Chen, Huanwen Bugrova, Anna Kononikhin, Alexey Bourmenskaya, Olga Brzhozovskiy, Alexander Polushkina, Evgeniya Kulikova, Galina Shchegolev, Alexander Trofimov, Dmitry Frankevich, Vladimir Nikolaev, Evgeny Shmakov, Roman G. Vertical Transmission of SARS-CoV-2 in Second Trimester Associated with Severe Neonatal Pathology |
title | Vertical Transmission of SARS-CoV-2 in Second Trimester Associated with Severe Neonatal Pathology |
title_full | Vertical Transmission of SARS-CoV-2 in Second Trimester Associated with Severe Neonatal Pathology |
title_fullStr | Vertical Transmission of SARS-CoV-2 in Second Trimester Associated with Severe Neonatal Pathology |
title_full_unstemmed | Vertical Transmission of SARS-CoV-2 in Second Trimester Associated with Severe Neonatal Pathology |
title_short | Vertical Transmission of SARS-CoV-2 in Second Trimester Associated with Severe Neonatal Pathology |
title_sort | vertical transmission of sars-cov-2 in second trimester associated with severe neonatal pathology |
topic | Case Report |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7999228/ https://www.ncbi.nlm.nih.gov/pubmed/33801923 http://dx.doi.org/10.3390/v13030447 |
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