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World-Wide Prevalence and Genotype Distribution of Enteroviruses

Enteroviruses (EVs) are highly prevalent viruses world-wide, causing a wide range of diseases in both children and adults. Insight in the global prevalence of EVs is important to define their clinical significance and total disease burden, and assists in making therapeutic decisions. While many stud...

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Autores principales: Brouwer, Lieke, Moreni, Giulia, Wolthers, Katja C., Pajkrt, Dasja
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7999254/
https://www.ncbi.nlm.nih.gov/pubmed/33800518
http://dx.doi.org/10.3390/v13030434
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author Brouwer, Lieke
Moreni, Giulia
Wolthers, Katja C.
Pajkrt, Dasja
author_facet Brouwer, Lieke
Moreni, Giulia
Wolthers, Katja C.
Pajkrt, Dasja
author_sort Brouwer, Lieke
collection PubMed
description Enteroviruses (EVs) are highly prevalent viruses world-wide, causing a wide range of diseases in both children and adults. Insight in the global prevalence of EVs is important to define their clinical significance and total disease burden, and assists in making therapeutic decisions. While many studies have been conducted to describe epidemiology of EVs in specific (sub)populations and patient cohorts, little effort has been made to aggregate the available evidence. In the current study, we conducted a search in the PubMed and Embase (Ovid) databases to identify articles reporting EV prevalence and type distribution. We summarized the findings of 153 included studies. We found that EVs are highly prevalent viruses in all continents. Enterovirus B was the most detected species worldwide, while the other species showed continent-specific differences, with Enterovirus C more detected in Africa and Enterovirus A more detected in Asia. Echovirus 30 was by far the most detected type, especially in studies conducted in Europe. EV types in species Enterovirus B—including echovirus 30—were often detected in patient groups with neurological infections and in cerebrospinal fluid, while Enterovirus C types were often found in stool samples.
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spelling pubmed-79992542021-03-28 World-Wide Prevalence and Genotype Distribution of Enteroviruses Brouwer, Lieke Moreni, Giulia Wolthers, Katja C. Pajkrt, Dasja Viruses Review Enteroviruses (EVs) are highly prevalent viruses world-wide, causing a wide range of diseases in both children and adults. Insight in the global prevalence of EVs is important to define their clinical significance and total disease burden, and assists in making therapeutic decisions. While many studies have been conducted to describe epidemiology of EVs in specific (sub)populations and patient cohorts, little effort has been made to aggregate the available evidence. In the current study, we conducted a search in the PubMed and Embase (Ovid) databases to identify articles reporting EV prevalence and type distribution. We summarized the findings of 153 included studies. We found that EVs are highly prevalent viruses in all continents. Enterovirus B was the most detected species worldwide, while the other species showed continent-specific differences, with Enterovirus C more detected in Africa and Enterovirus A more detected in Asia. Echovirus 30 was by far the most detected type, especially in studies conducted in Europe. EV types in species Enterovirus B—including echovirus 30—were often detected in patient groups with neurological infections and in cerebrospinal fluid, while Enterovirus C types were often found in stool samples. MDPI 2021-03-08 /pmc/articles/PMC7999254/ /pubmed/33800518 http://dx.doi.org/10.3390/v13030434 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) ).
spellingShingle Review
Brouwer, Lieke
Moreni, Giulia
Wolthers, Katja C.
Pajkrt, Dasja
World-Wide Prevalence and Genotype Distribution of Enteroviruses
title World-Wide Prevalence and Genotype Distribution of Enteroviruses
title_full World-Wide Prevalence and Genotype Distribution of Enteroviruses
title_fullStr World-Wide Prevalence and Genotype Distribution of Enteroviruses
title_full_unstemmed World-Wide Prevalence and Genotype Distribution of Enteroviruses
title_short World-Wide Prevalence and Genotype Distribution of Enteroviruses
title_sort world-wide prevalence and genotype distribution of enteroviruses
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7999254/
https://www.ncbi.nlm.nih.gov/pubmed/33800518
http://dx.doi.org/10.3390/v13030434
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