Perspectives on New Vaccines against Arboviruses Using Insect-Specific Viruses as Platforms

Arthropod-borne viruses (arboviruses) are global pathogens circulating endemically with local explosive outbreaks and constant encroachment into new locations. Few vaccines against arboviruses exist; most for humans are in development or clinical trials. Insect-specific viruses (ISVs) offer a unique...

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Detalles Bibliográficos
Autores principales: Carvalho, Valéria L., Long, Maureen T.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7999276/
https://www.ncbi.nlm.nih.gov/pubmed/33809576
http://dx.doi.org/10.3390/vaccines9030263
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author Carvalho, Valéria L.
Long, Maureen T.
author_facet Carvalho, Valéria L.
Long, Maureen T.
author_sort Carvalho, Valéria L.
collection PubMed
description Arthropod-borne viruses (arboviruses) are global pathogens circulating endemically with local explosive outbreaks and constant encroachment into new locations. Few vaccines against arboviruses exist; most for humans are in development or clinical trials. Insect-specific viruses (ISVs) offer a unique platform for expression of arbovirus proteins, through the creation of ISV/arbovirus chimeras. Studies have shown promising results of these vaccines with several advantages over their wild-type counterparts. In this review, we discuss the current status of these potential vaccines using ISVs.
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spelling pubmed-79992762021-03-28 Perspectives on New Vaccines against Arboviruses Using Insect-Specific Viruses as Platforms Carvalho, Valéria L. Long, Maureen T. Vaccines (Basel) Review Arthropod-borne viruses (arboviruses) are global pathogens circulating endemically with local explosive outbreaks and constant encroachment into new locations. Few vaccines against arboviruses exist; most for humans are in development or clinical trials. Insect-specific viruses (ISVs) offer a unique platform for expression of arbovirus proteins, through the creation of ISV/arbovirus chimeras. Studies have shown promising results of these vaccines with several advantages over their wild-type counterparts. In this review, we discuss the current status of these potential vaccines using ISVs. MDPI 2021-03-16 /pmc/articles/PMC7999276/ /pubmed/33809576 http://dx.doi.org/10.3390/vaccines9030263 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) ).
spellingShingle Review
Carvalho, Valéria L.
Long, Maureen T.
Perspectives on New Vaccines against Arboviruses Using Insect-Specific Viruses as Platforms
title Perspectives on New Vaccines against Arboviruses Using Insect-Specific Viruses as Platforms
title_full Perspectives on New Vaccines against Arboviruses Using Insect-Specific Viruses as Platforms
title_fullStr Perspectives on New Vaccines against Arboviruses Using Insect-Specific Viruses as Platforms
title_full_unstemmed Perspectives on New Vaccines against Arboviruses Using Insect-Specific Viruses as Platforms
title_short Perspectives on New Vaccines against Arboviruses Using Insect-Specific Viruses as Platforms
title_sort perspectives on new vaccines against arboviruses using insect-specific viruses as platforms
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7999276/
https://www.ncbi.nlm.nih.gov/pubmed/33809576
http://dx.doi.org/10.3390/vaccines9030263
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